Alteration of PTGS2 Promoter Methylation in Chronic Periodontitis

Levels of prostaglandin E2 and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that chronic inflammation is associated with altered DNA methylation levels within the PTGS2 promoter, wit...

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Veröffentlicht in:	Journal of dental research 2010-02, Vol.89 (2), p.133-137
Hauptverfasser:	Zhang, S., Barros, S.P., Niculescu, M.D., Moretti, A.J., Preisser, J.S., Offenbacher, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Case-Control Studies Chronic Periodontitis - enzymology Chronic Periodontitis - genetics CpG Islands - genetics Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - genetics Dentistry DNA Methylation Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gene Expression Regulation, Enzymologic Humans Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Promoter Regions, Genetic Research Report RNA, Messenger - biosynthesis Transcription, Genetic Young Adult
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