In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH

The aspartic protease cathepsin E has been shown to induce apoptosis in cancer cells under physiological conditions. Therefore, cathepsin E-activity-enhancing peptides functioning in the physiological pH range are valuable potential cancer therapeutic candidates. Here, we have used a general in vitr...

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Veröffentlicht in:	International journal of peptides 2011, Vol.2011 (2011), p.1-10
Hauptverfasser:	Futakami, Masae, Biyani, Madhu, Kitamura, Koichiro, Kawakubo, Tomoyo, Suzuki, Miho, Yamamoto, Kenji, Nishigaki, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Aptamers aspartic endopeptidase Cancer Cathepsin E cathepsins Evolution Kinases Libraries Materials science Panning pH effects Proteins Small & medium sized enterprises-SME Technological change
Online-Zugang:	Volltext
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