Phosphorylation of human Argonaute proteins affects small RNA binding

Argonaute (Ago) proteins are highly conserved between species and constitute a direct-binding platform for small RNAs including short-interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi interacting RNAs (piRNAs). Small RNAs function as guides whereas Ago proteins are the actual mediators of gene...

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Veröffentlicht in:	Nucleic acids research 2011-03, Vol.39 (6), p.2330-2343
Hauptverfasser:	Rüdel, Sabine, Wang, Yanli, Lenobel, René, Körner, Roman, Hsiao, He-Hsuan, Urlaub, Henning, Patel, Dinshaw, Meister, Gunter
Format:	Artikel
Sprache:	eng
Schlagworte:	Argonaute 2 protein Argonaute Proteins Data processing Eukaryotic Initiation Factor-2 - chemistry Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factors - chemistry Eukaryotic Initiation Factors - genetics Eukaryotic Initiation Factors - metabolism Gene silencing Glutamic acid HEK293 Cells Humans Mimicry miRNA Mutation Phosphate Phosphorylation Phosphotyrosine - chemistry Protein Binding Protein Structure, Tertiary Ribonuclease III - metabolism RNA RNA, Small Interfering - metabolism RNA, Small Untranslated - metabolism RNA-Binding Proteins - metabolism siRNA Tyrosine Tyrosine - metabolism
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