A molecular-imprint nanosensor for ultrasensitive detection of proteins
Molecular imprinting is a technique for preparing polymer scaffolds that function as synthetic receptors 1 , 2 , 3 . Imprinted polymers that can selectively bind organic compounds have proven useful in sensor development 2 , 3 , 4 , 5 , 6 , 7 . Although creating synthetic molecular-imprinting polyme...
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| Veröffentlicht in: | Nature nanotechnology 2010-08, Vol.5 (8), p.597-601 |
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| creator | Cai, Dong Ren, Lu Zhao, Huaizhou Xu, Chenjia Zhang, Lu Yu, Ying Wang, Hengzhi Lan, Yucheng Roberts, Mary F. Chuang, Jeffrey H. Naughton, Michael J. Ren, Zhifeng Chiles, Thomas C. |
| description | Molecular imprinting is a technique for preparing polymer scaffolds that function as synthetic receptors
1
,
2
,
3
. Imprinted polymers that can selectively bind organic compounds have proven useful in sensor development
2
,
3
,
4
,
5
,
6
,
7
. Although creating synthetic molecular-imprinting polymers that recognize proteins remains challenging
8
,
9
,
10
,
11
, nanodevices and nanomaterials show promise in this area
12
,
13
,
14
. Here, we show that arrays of carbon-nanotube tips with an imprinted non-conducting polymer coating can recognize proteins with subpicogram per litre sensitivity using electrochemical impedance spectroscopy. We have developed molecular-imprinting sensors specific for human ferritin and human papillomavirus derived E7 protein. The molecular-imprinting-based nanosensor can also discriminate between Ca
2+
-induced conformational changes in calmodulin. This ultrasensitive, label-free electrochemical detection of proteins offers an alternative to biosensors based on biomolecule recognition.
Carbon nanotube tips containing imprints within a non-conducting polymer coating can detect proteins with high sensitivity, offering a label-free alternative to sensors based on biomolecule recognition. |
| doi_str_mv | 10.1038/nnano.2010.114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3064708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2356966101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-4affcaeee993dbbc6123f5ac954b8af2efc053f43f9822cd4fc15d06ac5d28dc3</originalsourceid><addsrcrecordid>eNp1kUtPxCAUhYnR-BjdujSNG1cdKY8ObEyM8ZWYuNE1YehlxLQwQmviv5c6Oj4SFwRu-Dicew9ChxWeVpiKU--1D1OCx7piG2i3mjFRUir55vosZjtoL6VnjDmRhG2jHYK5qATlu-j6vOhCC2ZodSxdt4zO98WomcCnEAub19D2UY-1690rFA30YHoXfBFssYyhB-fTPtqyuk1w8LlP0OPV5cPFTXl3f317cX5XGsbrvmTaWqMBQErazOemrgi1XBvJ2VxoS8AazKll1EpBiGmYNRVvcK0Nb4hoDJ2gs5Xucph30Bjw2Vursu9OxzcVtFO_b7x7Uovwqiiu2QyLLHDyKRDDywCpV51LBtpWewhDUnlkMo8Py0we_yGfwxB97k6JWlDJJJ1laLqCTAwpRbBrKxVWY0LqIyE1JqRyQvnB0c8G1vhXJBk4XQFpDGMB8fvbfyTfAQYZoEk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>868394937</pqid></control><display><type>article</type><title>A molecular-imprint nanosensor for ultrasensitive detection of proteins</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><creator>Cai, Dong ; Ren, Lu ; Zhao, Huaizhou ; Xu, Chenjia ; Zhang, Lu ; Yu, Ying ; Wang, Hengzhi ; Lan, Yucheng ; Roberts, Mary F. ; Chuang, Jeffrey H. ; Naughton, Michael J. ; Ren, Zhifeng ; Chiles, Thomas C.</creator><creatorcontrib>Cai, Dong ; Ren, Lu ; Zhao, Huaizhou ; Xu, Chenjia ; Zhang, Lu ; Yu, Ying ; Wang, Hengzhi ; Lan, Yucheng ; Roberts, Mary F. ; Chuang, Jeffrey H. ; Naughton, Michael J. ; Ren, Zhifeng ; Chiles, Thomas C.</creatorcontrib><description>Molecular imprinting is a technique for preparing polymer scaffolds that function as synthetic receptors
1
,
2
,
3
. Imprinted polymers that can selectively bind organic compounds have proven useful in sensor development
2
,
3
,
4
,
5
,
6
,
7
. Although creating synthetic molecular-imprinting polymers that recognize proteins remains challenging
8
,
9
,
10
,
11
, nanodevices and nanomaterials show promise in this area
12
,
13
,
14
. Here, we show that arrays of carbon-nanotube tips with an imprinted non-conducting polymer coating can recognize proteins with subpicogram per litre sensitivity using electrochemical impedance spectroscopy. We have developed molecular-imprinting sensors specific for human ferritin and human papillomavirus derived E7 protein. The molecular-imprinting-based nanosensor can also discriminate between Ca
2+
-induced conformational changes in calmodulin. This ultrasensitive, label-free electrochemical detection of proteins offers an alternative to biosensors based on biomolecule recognition.
Carbon nanotube tips containing imprints within a non-conducting polymer coating can detect proteins with high sensitivity, offering a label-free alternative to sensors based on biomolecule recognition.</description><identifier>ISSN: 1748-3387</identifier><identifier>EISSN: 1748-3395</identifier><identifier>DOI: 10.1038/nnano.2010.114</identifier><identifier>PMID: 20581835</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/612 ; 639/925/927/356 ; Arrays ; Biosensing Techniques - instrumentation ; Biosensors ; Chemistry and Materials Science ; Conductometry - instrumentation ; Electrochemistry ; Equipment Design ; Equipment Failure Analysis ; Glass substrates ; Impedance ; letter ; Materials Science ; Microscopy ; Molecular Probe Techniques - instrumentation ; Nanotechnology ; Nanotechnology - instrumentation ; Nanotechnology and Microengineering ; Organic compounds ; Polymers ; Protein Array Analysis - instrumentation ; Proteins ; Sensitivity and Specificity ; Sensors ; Spectroscopy</subject><ispartof>Nature nanotechnology, 2010-08, Vol.5 (8), p.597-601</ispartof><rights>Springer Nature Limited 2010</rights><rights>Copyright Nature Publishing Group Aug 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-4affcaeee993dbbc6123f5ac954b8af2efc053f43f9822cd4fc15d06ac5d28dc3</citedby><cites>FETCH-LOGICAL-c456t-4affcaeee993dbbc6123f5ac954b8af2efc053f43f9822cd4fc15d06ac5d28dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nnano.2010.114$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nnano.2010.114$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20581835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Dong</creatorcontrib><creatorcontrib>Ren, Lu</creatorcontrib><creatorcontrib>Zhao, Huaizhou</creatorcontrib><creatorcontrib>Xu, Chenjia</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Yu, Ying</creatorcontrib><creatorcontrib>Wang, Hengzhi</creatorcontrib><creatorcontrib>Lan, Yucheng</creatorcontrib><creatorcontrib>Roberts, Mary F.</creatorcontrib><creatorcontrib>Chuang, Jeffrey H.</creatorcontrib><creatorcontrib>Naughton, Michael J.</creatorcontrib><creatorcontrib>Ren, Zhifeng</creatorcontrib><creatorcontrib>Chiles, Thomas C.</creatorcontrib><title>A molecular-imprint nanosensor for ultrasensitive detection of proteins</title><title>Nature nanotechnology</title><addtitle>Nature Nanotech</addtitle><addtitle>Nat Nanotechnol</addtitle><description>Molecular imprinting is a technique for preparing polymer scaffolds that function as synthetic receptors
1
,
2
,
3
. Imprinted polymers that can selectively bind organic compounds have proven useful in sensor development
2
,
3
,
4
,
5
,
6
,
7
. Although creating synthetic molecular-imprinting polymers that recognize proteins remains challenging
8
,
9
,
10
,
11
, nanodevices and nanomaterials show promise in this area
12
,
13
,
14
. Here, we show that arrays of carbon-nanotube tips with an imprinted non-conducting polymer coating can recognize proteins with subpicogram per litre sensitivity using electrochemical impedance spectroscopy. We have developed molecular-imprinting sensors specific for human ferritin and human papillomavirus derived E7 protein. The molecular-imprinting-based nanosensor can also discriminate between Ca
2+
-induced conformational changes in calmodulin. This ultrasensitive, label-free electrochemical detection of proteins offers an alternative to biosensors based on biomolecule recognition.
Carbon nanotube tips containing imprints within a non-conducting polymer coating can detect proteins with high sensitivity, offering a label-free alternative to sensors based on biomolecule recognition.</description><subject>631/45/612</subject><subject>639/925/927/356</subject><subject>Arrays</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensors</subject><subject>Chemistry and Materials Science</subject><subject>Conductometry - instrumentation</subject><subject>Electrochemistry</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Glass substrates</subject><subject>Impedance</subject><subject>letter</subject><subject>Materials Science</subject><subject>Microscopy</subject><subject>Molecular Probe Techniques - instrumentation</subject><subject>Nanotechnology</subject><subject>Nanotechnology - instrumentation</subject><subject>Nanotechnology and Microengineering</subject><subject>Organic compounds</subject><subject>Polymers</subject><subject>Protein Array Analysis - instrumentation</subject><subject>Proteins</subject><subject>Sensitivity and Specificity</subject><subject>Sensors</subject><subject>Spectroscopy</subject><issn>1748-3387</issn><issn>1748-3395</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtPxCAUhYnR-BjdujSNG1cdKY8ObEyM8ZWYuNE1YehlxLQwQmviv5c6Oj4SFwRu-Dicew9ChxWeVpiKU--1D1OCx7piG2i3mjFRUir55vosZjtoL6VnjDmRhG2jHYK5qATlu-j6vOhCC2ZodSxdt4zO98WomcCnEAub19D2UY-1690rFA30YHoXfBFssYyhB-fTPtqyuk1w8LlP0OPV5cPFTXl3f317cX5XGsbrvmTaWqMBQErazOemrgi1XBvJ2VxoS8AazKll1EpBiGmYNRVvcK0Nb4hoDJ2gs5Xucph30Bjw2Vursu9OxzcVtFO_b7x7Uovwqiiu2QyLLHDyKRDDywCpV51LBtpWewhDUnlkMo8Py0we_yGfwxB97k6JWlDJJJ1laLqCTAwpRbBrKxVWY0LqIyE1JqRyQvnB0c8G1vhXJBk4XQFpDGMB8fvbfyTfAQYZoEk</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Cai, Dong</creator><creator>Ren, Lu</creator><creator>Zhao, Huaizhou</creator><creator>Xu, Chenjia</creator><creator>Zhang, Lu</creator><creator>Yu, Ying</creator><creator>Wang, Hengzhi</creator><creator>Lan, Yucheng</creator><creator>Roberts, Mary F.</creator><creator>Chuang, Jeffrey H.</creator><creator>Naughton, Michael J.</creator><creator>Ren, Zhifeng</creator><creator>Chiles, Thomas C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100801</creationdate><title>A molecular-imprint nanosensor for ultrasensitive detection of proteins</title><author>Cai, Dong ; Ren, Lu ; Zhao, Huaizhou ; Xu, Chenjia ; Zhang, Lu ; Yu, Ying ; Wang, Hengzhi ; Lan, Yucheng ; Roberts, Mary F. ; Chuang, Jeffrey H. ; Naughton, Michael J. ; Ren, Zhifeng ; Chiles, Thomas C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-4affcaeee993dbbc6123f5ac954b8af2efc053f43f9822cd4fc15d06ac5d28dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/45/612</topic><topic>639/925/927/356</topic><topic>Arrays</topic><topic>Biosensing Techniques - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature nanotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Dong</au><au>Ren, Lu</au><au>Zhao, Huaizhou</au><au>Xu, Chenjia</au><au>Zhang, Lu</au><au>Yu, Ying</au><au>Wang, Hengzhi</au><au>Lan, Yucheng</au><au>Roberts, Mary F.</au><au>Chuang, Jeffrey H.</au><au>Naughton, Michael J.</au><au>Ren, Zhifeng</au><au>Chiles, Thomas C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A molecular-imprint nanosensor for ultrasensitive detection of proteins</atitle><jtitle>Nature nanotechnology</jtitle><stitle>Nature Nanotech</stitle><addtitle>Nat Nanotechnol</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>5</volume><issue>8</issue><spage>597</spage><epage>601</epage><pages>597-601</pages><issn>1748-3387</issn><eissn>1748-3395</eissn><abstract>Molecular imprinting is a technique for preparing polymer scaffolds that function as synthetic receptors
1
,
2
,
3
. Imprinted polymers that can selectively bind organic compounds have proven useful in sensor development
2
,
3
,
4
,
5
,
6
,
7
. Although creating synthetic molecular-imprinting polymers that recognize proteins remains challenging
8
,
9
,
10
,
11
, nanodevices and nanomaterials show promise in this area
12
,
13
,
14
. Here, we show that arrays of carbon-nanotube tips with an imprinted non-conducting polymer coating can recognize proteins with subpicogram per litre sensitivity using electrochemical impedance spectroscopy. We have developed molecular-imprinting sensors specific for human ferritin and human papillomavirus derived E7 protein. The molecular-imprinting-based nanosensor can also discriminate between Ca
2+
-induced conformational changes in calmodulin. This ultrasensitive, label-free electrochemical detection of proteins offers an alternative to biosensors based on biomolecule recognition.
Carbon nanotube tips containing imprints within a non-conducting polymer coating can detect proteins with high sensitivity, offering a label-free alternative to sensors based on biomolecule recognition.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20581835</pmid><doi>10.1038/nnano.2010.114</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | 631/45/612 639/925/927/356 Arrays Biosensing Techniques - instrumentation Biosensors Chemistry and Materials Science Conductometry - instrumentation Electrochemistry Equipment Design Equipment Failure Analysis Glass substrates Impedance letter Materials Science Microscopy Molecular Probe Techniques - instrumentation Nanotechnology Nanotechnology - instrumentation Nanotechnology and Microengineering Organic compounds Polymers Protein Array Analysis - instrumentation Proteins Sensitivity and Specificity Sensors Spectroscopy |
| title | A molecular-imprint nanosensor for ultrasensitive detection of proteins |
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