MEKs/ERKs inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by down regulating growth and DNA repair signals

Multimodal treatment has improved the outcome of many solid tumors, and in some cases the use of radiosensitizers has significantly contributed to this gain. Activation of the extracellular signaling kinase pathway (MEK/ERK) generally results in stimulation of cell growth and confers a survival adva...

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Veröffentlicht in:	Molecular cancer therapeutics 2011-01, Vol.10 (1), p.159-168
Hauptverfasser:	Marampon, Francesco, Gravina, Giovanni Luca, Di Rocco, Agnese, Bonfili, Pierluigi, Di Staso, Mario, Fardella, Caterina, Polidoro, Lorella, Ciccarelli, Carmela, Festuccia, Claudio, Popov, Vladimir M., Pestell, Richard G., Tombolini, Vincenzo, Zani, Bianca Maria
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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