A Randomized Clinical Trial of the Effects of Supplemental Calcium and Vitamin D3 on Markers of Their Metabolism in Normal Mucosa of Colorectal Adenoma Patients

In cancer cell lines and rodent models, calcium and vitamin D favorably modulate cell proliferation, differentiation, and apoptosis in colonic epithelia. These effects may be modulated by local expression of the calcium receptor (CaR), the vitamin D receptor (VDR), and the P450 cytochromes, CYP27B1...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-01, Vol.71 (2), p.413-423
Hauptverfasser:	AHEARN, Thomas U, MCCULLOUGH, Marjorie L, FLANDERS, W. Dana, QI LONG, SIDELNIKOV, Eduard, FEDIRKO, Veronika, DANIEL, Carrie R, RUTHERFORD, Robin E, SHAUKAT, Aasma, BOSTICK, Roberd M
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - biosynthesis Adenoma Adenoma - blood Adenoma - drug therapy Adenoma - metabolism Animal models Antineoplastic agents Apoptosis Biological and medical sciences biomarkers Biomarkers, Tumor - metabolism Biopsy Calcium Calcium - administration & dosage Calcium - metabolism Cell proliferation chemopreventive agents Cholecalciferol - administration & dosage Clinical trials Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - prevention & control Cytochromes Differentiation Double-Blind Method Female Gastroenterology. Liver. Pancreas. Abdomen Humans Image processing Immunohistochemistry Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Male Medical sciences Metabolism Middle Aged Mucosa Pharmacology. Drug treatments Pilot Projects Precancerous Conditions - blood Precancerous Conditions - drug therapy Precancerous Conditions - metabolism Receptors, Calcitriol - biosynthesis Receptors, Calcium-Sensing - biosynthesis Rectum Steroid Hydroxylases - biosynthesis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor cell lines Tumors Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D receptors Vitamin D3 Vitamin D3 24-Hydroxylase
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