Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats

Alterations in the balance between ANG II/ACE and ANG 1-7/ACE2 in ANG II-dependent hypertension could reduce the generation of ANG 1-7 and contribute further to increased intrarenal ANG II. Upregulation of collecting duct (CD) renin may lead to increased ANG II formation during ANG II-dependent hype...

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Veröffentlicht in:	American Journal of Physiology - Renal Physiology 2011-03, Vol.300 (3), p.F749-F755
Hauptverfasser:	Prieto, Minolfa C, González-Villalobos, Romer A, Botros, Fady T, Martin, Victoria L, Pagán, Javier, Satou, Ryousuke, Lara, Lucienne S, Feng, Yumei, Fernandes, Fernanda B, Kobori, Hiroyuki, Casarini, Dulce E, Navar, L Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Angiotensin I - metabolism Angiotensin II - metabolism Animals Blood Pressure - physiology Disease Models, Animal Gene expression Hypertension Hypertension, Renovascular - metabolism Kidney - metabolism Kidney Cortex - metabolism Kidney diseases Kidney Medulla - metabolism Kidney Tubules, Collecting - metabolism Male Peptide Fragments - metabolism Peptides Peptidyl-Dipeptidase A - metabolism Proteins Rats Renin - metabolism RNA, Messenger - metabolism Rodents
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