Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats
▶ Bilateral infusion of 100 ng tropisetron to the medial basal hypothalamus inhibited lordosis behavior of ovariectomized, hormonally primed rats while infusion of 10 or 25 ng had no effect on lordosis behavior. ▶ Five minutes restraint had no effect on lordosis behavior when ovariectomized, hormona...
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| creator | Uphouse, Lynda Heckard, Danyeal Hiegel, Cindy Guptarak, Jutatip Maswood, Sharmin |
| description | ▶ Bilateral infusion of 100
ng tropisetron to the medial basal hypothalamus inhibited lordosis behavior of ovariectomized, hormonally primed rats while infusion of 10 or 25
ng had no effect on lordosis behavior. ▶ Five minutes restraint had no effect on lordosis behavior when ovariectomized, hormonally primed rats were infused with deionized water; however, when restraint occurred 15
min after infusion with 10 or 25
ng tropisetron, lordosis behavior was reduced. ▶ In contrast to intracranial effects of tropisetron, intraperitoneal treatment with the drug did not affect the response to stress.
Ovariectomized rats, hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone are resistant to the lordosis-inhibiting effects of a 5
min restraint experience. However, modulation of the serotonergic (5-HT) system alters this resistance to stress. In the following experiment, ovariectomized Fischer inbred rats were hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone. The effect of 5
min restraint on sexual behavior was examined after bilateral hypothalamic infusion or intraperitoneal (ip) treatment with the 5-HT
3 receptor antagonist, 3-tropanylindole-3-carboxylate hydrochloride (tropisetron). Infusion with 50 or 100
ng tropisetron inhibited lordosis behavior. When rats were infused with 10 or 25
ng tropisetron, rats showed normal lordosis behavior. However, when infusion with 10 or 25
ng tropisetron was combined with 5
min restraint, lordosis behavior was inhibited. These findings are consistent with prior work that has implicated hypothalamic serotonin in control of lordosis behavior and in the effect of mild restraint on the behavior. In contrast to the effects of the intracranial infusion, intraperitoneal injection with 1.0 or 2.0
mg/kg tropisetron did not amplify the effects of restraint. |
| doi_str_mv | 10.1016/j.bbr.2011.01.006 |
| format | Article |
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ng tropisetron to the medial basal hypothalamus inhibited lordosis behavior of ovariectomized, hormonally primed rats while infusion of 10 or 25
ng had no effect on lordosis behavior. ▶ Five minutes restraint had no effect on lordosis behavior when ovariectomized, hormonally primed rats were infused with deionized water; however, when restraint occurred 15
min after infusion with 10 or 25
ng tropisetron, lordosis behavior was reduced. ▶ In contrast to intracranial effects of tropisetron, intraperitoneal treatment with the drug did not affect the response to stress.
Ovariectomized rats, hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone are resistant to the lordosis-inhibiting effects of a 5
min restraint experience. However, modulation of the serotonergic (5-HT) system alters this resistance to stress. In the following experiment, ovariectomized Fischer inbred rats were hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone. The effect of 5
min restraint on sexual behavior was examined after bilateral hypothalamic infusion or intraperitoneal (ip) treatment with the 5-HT
3 receptor antagonist, 3-tropanylindole-3-carboxylate hydrochloride (tropisetron). Infusion with 50 or 100
ng tropisetron inhibited lordosis behavior. When rats were infused with 10 or 25
ng tropisetron, rats showed normal lordosis behavior. However, when infusion with 10 or 25
ng tropisetron was combined with 5
min restraint, lordosis behavior was inhibited. These findings are consistent with prior work that has implicated hypothalamic serotonin in control of lordosis behavior and in the effect of mild restraint on the behavior. In contrast to the effects of the intracranial infusion, intraperitoneal injection with 1.0 or 2.0
mg/kg tropisetron did not amplify the effects of restraint.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2011.01.006</identifier><identifier>PMID: 21238491</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>5-HT 3 receptors ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Diseases of the osteoarticular system ; Diseases of the spine ; Estradiol - analogs & derivatives ; Estradiol - pharmacology ; Female ; Female rats ; Fundamental and applied biological sciences. Psychology ; Handling (Psychology) ; Indoles - administration & dosage ; Indoles - pharmacology ; Injections ; Injections, Intraperitoneal ; Intracranial infusion ; Intraperitoneal treatment ; Lordosis ; Medical sciences ; Ovariectomy ; Posture ; Progesterone - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Inbred F344 ; Restraint, Physical ; Serotonin ; Serotonin Antagonists - administration & dosage ; Serotonin Antagonists - pharmacology ; Sexual Behavior, Animal - drug effects ; Stress, Psychological - psychology ; Ventromedial hypothalamus</subject><ispartof>Behavioural brain research, 2011-06, Vol.219 (2), p.221-226</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-b57273902f626ade02a18f0ddd19c86b9e664e946905da1e48dbc5ed3c0e2a743</citedby><cites>FETCH-LOGICAL-c512t-b57273902f626ade02a18f0ddd19c86b9e664e946905da1e48dbc5ed3c0e2a743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2011.01.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24030695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21238491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uphouse, Lynda</creatorcontrib><creatorcontrib>Heckard, Danyeal</creatorcontrib><creatorcontrib>Hiegel, Cindy</creatorcontrib><creatorcontrib>Guptarak, Jutatip</creatorcontrib><creatorcontrib>Maswood, Sharmin</creatorcontrib><title>Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>▶ Bilateral infusion of 100
ng tropisetron to the medial basal hypothalamus inhibited lordosis behavior of ovariectomized, hormonally primed rats while infusion of 10 or 25
ng had no effect on lordosis behavior. ▶ Five minutes restraint had no effect on lordosis behavior when ovariectomized, hormonally primed rats were infused with deionized water; however, when restraint occurred 15
min after infusion with 10 or 25
ng tropisetron, lordosis behavior was reduced. ▶ In contrast to intracranial effects of tropisetron, intraperitoneal treatment with the drug did not affect the response to stress.
Ovariectomized rats, hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone are resistant to the lordosis-inhibiting effects of a 5
min restraint experience. However, modulation of the serotonergic (5-HT) system alters this resistance to stress. In the following experiment, ovariectomized Fischer inbred rats were hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone. The effect of 5
min restraint on sexual behavior was examined after bilateral hypothalamic infusion or intraperitoneal (ip) treatment with the 5-HT
3 receptor antagonist, 3-tropanylindole-3-carboxylate hydrochloride (tropisetron). Infusion with 50 or 100
ng tropisetron inhibited lordosis behavior. When rats were infused with 10 or 25
ng tropisetron, rats showed normal lordosis behavior. However, when infusion with 10 or 25
ng tropisetron was combined with 5
min restraint, lordosis behavior was inhibited. These findings are consistent with prior work that has implicated hypothalamic serotonin in control of lordosis behavior and in the effect of mild restraint on the behavior. In contrast to the effects of the intracranial infusion, intraperitoneal injection with 1.0 or 2.0
mg/kg tropisetron did not amplify the effects of restraint.</description><subject>5-HT 3 receptors</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Female rats</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Handling (Psychology)</subject><subject>Indoles - administration & dosage</subject><subject>Indoles - pharmacology</subject><subject>Injections</subject><subject>Injections, Intraperitoneal</subject><subject>Intracranial infusion</subject><subject>Intraperitoneal treatment</subject><subject>Lordosis</subject><subject>Medical sciences</subject><subject>Ovariectomy</subject><subject>Posture</subject><subject>Progesterone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Restraint, Physical</subject><subject>Serotonin</subject><subject>Serotonin Antagonists - administration & dosage</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Stress, Psychological - psychology</subject><subject>Ventromedial hypothalamus</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYMo7rj6AXyRvIgv29mbNE1bBEEW_yws7Mv6HNLk1mZokzHpDMzihzdlxlVfVrgQkvzuybk5hLxmsGbA5OVm3XVxzYGxNeQC-YSsWFPzoq5E-5SsMiMLUfLmjLxIaQMAAir2nJxxxstGtGxFft7FsHUJ5xg8dd5E1AkTnQfMu8F1bg7xQLHv0cw09HRyo6UR0xy18_nE0zFEG5JLtMNB712ICzaEOAWvx_FAt9FNaC9o2OvoskqY3D1mDT2nl-RZr8eEr07rOfn2-dPd1dfi5vbL9dXHm8JUjM9FV9W8LlvgveRSWwSuWdODtZa1ppFdi1IKbIVsobKaoWhsZyq0pQHkuhblOflw1N3uuuzFoM_2R7U40_Gggnbq3xvvBvU97FUJMr-8CLw7CcTwY5enV5NLBsdRewy7pBpZ14KV0P6frBre8FrwTLIjaWJIKWL_4IeBWuJVG5XjVUu8CnKBzD1v_h7koeN3nhl4ewJ0Mnrso_bGpT-cgDxSW2Xu_ZHD_O17h1El49AbtC7mjJQN7hEbvwCkLcZ8</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Uphouse, Lynda</creator><creator>Heckard, Danyeal</creator><creator>Hiegel, Cindy</creator><creator>Guptarak, Jutatip</creator><creator>Maswood, Sharmin</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats</title><author>Uphouse, Lynda ; Heckard, Danyeal ; Hiegel, Cindy ; Guptarak, Jutatip ; Maswood, Sharmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-b57273902f626ade02a18f0ddd19c86b9e664e946905da1e48dbc5ed3c0e2a743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>5-HT 3 receptors</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Female rats</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Handling (Psychology)</topic><topic>Indoles - administration & dosage</topic><topic>Indoles - pharmacology</topic><topic>Injections</topic><topic>Injections, Intraperitoneal</topic><topic>Intracranial infusion</topic><topic>Intraperitoneal treatment</topic><topic>Lordosis</topic><topic>Medical sciences</topic><topic>Ovariectomy</topic><topic>Posture</topic><topic>Progesterone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Restraint, Physical</topic><topic>Serotonin</topic><topic>Serotonin Antagonists - administration & dosage</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Stress, Psychological - psychology</topic><topic>Ventromedial hypothalamus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uphouse, Lynda</creatorcontrib><creatorcontrib>Heckard, Danyeal</creatorcontrib><creatorcontrib>Hiegel, Cindy</creatorcontrib><creatorcontrib>Guptarak, Jutatip</creatorcontrib><creatorcontrib>Maswood, Sharmin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uphouse, Lynda</au><au>Heckard, Danyeal</au><au>Hiegel, Cindy</au><au>Guptarak, Jutatip</au><au>Maswood, Sharmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>219</volume><issue>2</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>▶ Bilateral infusion of 100
ng tropisetron to the medial basal hypothalamus inhibited lordosis behavior of ovariectomized, hormonally primed rats while infusion of 10 or 25
ng had no effect on lordosis behavior. ▶ Five minutes restraint had no effect on lordosis behavior when ovariectomized, hormonally primed rats were infused with deionized water; however, when restraint occurred 15
min after infusion with 10 or 25
ng tropisetron, lordosis behavior was reduced. ▶ In contrast to intracranial effects of tropisetron, intraperitoneal treatment with the drug did not affect the response to stress.
Ovariectomized rats, hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone are resistant to the lordosis-inhibiting effects of a 5
min restraint experience. However, modulation of the serotonergic (5-HT) system alters this resistance to stress. In the following experiment, ovariectomized Fischer inbred rats were hormonally primed with 10
μg estradiol benzoate and 500
μg progesterone. The effect of 5
min restraint on sexual behavior was examined after bilateral hypothalamic infusion or intraperitoneal (ip) treatment with the 5-HT
3 receptor antagonist, 3-tropanylindole-3-carboxylate hydrochloride (tropisetron). Infusion with 50 or 100
ng tropisetron inhibited lordosis behavior. When rats were infused with 10 or 25
ng tropisetron, rats showed normal lordosis behavior. However, when infusion with 10 or 25
ng tropisetron was combined with 5
min restraint, lordosis behavior was inhibited. These findings are consistent with prior work that has implicated hypothalamic serotonin in control of lordosis behavior and in the effect of mild restraint on the behavior. In contrast to the effects of the intracranial infusion, intraperitoneal injection with 1.0 or 2.0
mg/kg tropisetron did not amplify the effects of restraint.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>21238491</pmid><doi>10.1016/j.bbr.2011.01.006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Behavioural brain research, 2011-06, Vol.219 (2), p.221-226 |
| issn | 0166-4328 1872-7549 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-HT 3 receptors Animals Behavioral psychophysiology Biological and medical sciences Brain Diseases of the osteoarticular system Diseases of the spine Estradiol - analogs & derivatives Estradiol - pharmacology Female Female rats Fundamental and applied biological sciences. Psychology Handling (Psychology) Indoles - administration & dosage Indoles - pharmacology Injections Injections, Intraperitoneal Intracranial infusion Intraperitoneal treatment Lordosis Medical sciences Ovariectomy Posture Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred F344 Restraint, Physical Serotonin Serotonin Antagonists - administration & dosage Serotonin Antagonists - pharmacology Sexual Behavior, Animal - drug effects Stress, Psychological - psychology Ventromedial hypothalamus |
| title | Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats |
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