Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases

The protein tyrosine phosphatase CD45 is an important regulator of Src-family kinase activity. We found that in the absence of CD45, natural killer (NK) cells are defective in protecting the host from mouse cytomegalovirus infection. We show that although CD45 is necessary for all immunoreceptor tyr...

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Veröffentlicht in:	Blood 2011-03, Vol.117 (11), p.3087-3095
Hauptverfasser:	Hesslein, David G.T., Palacios, Emil H., Sun, Joseph C., Beilke, Joshua N., Watson, Susan R., Weiss, Arthur, Lanier, Lewis L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Antibody-Dependent Cell Cytotoxicity - immunology Biological and medical sciences Cell Degranulation - immunology Cell Proliferation Hematologic and hematopoietic diseases Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Herpesviridae Infections - virology Immunobiology Interferon-gamma - biosynthesis Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - metabolism Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Killer Cells, Natural - physiology Leukocyte Common Antigens - deficiency Leukocyte Common Antigens - metabolism Medical sciences Mice Muromegalovirus - physiology NK Cell Lectin-Like Receptor Subfamily A - metabolism Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - metabolism Receptors, Virus - metabolism Syk Kinase ZAP-70 Protein-Tyrosine Kinase - metabolism
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