Digibind attenuates cytokine TNFα-induced endothelial inflammatory response: potential benefit role of Digibind in preeclampsia

Objective: Exaggerated inflammatory response occurs in preeclampsia. Preeclampsia is also associated with elevated endogenous digoxin-like factors (EDLFs). Clinical data suggest that Digibind (a polyclonal sheep digoxin binding Fab fragment) binds to EDLF and may have the potential to attenuate vaso...

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Veröffentlicht in:	Journal of perinatology 2009-03, Vol.29 (3), p.195-200
Hauptverfasser:	Wang, Y, Lewis, D F, Adair, C D, Gu, Y, Mason, L, Kipikasa, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Attenuation Blocking Cell culture Cell membranes Cytokines Digoxin Digoxin immune Fab Dosage and administration Drug therapy E-selectin Endothelial cells Extracellular signal-regulated kinase Health aspects Immunoassay Inflammation Inflammatory response Kinases Medicine Medicine & Public Health Na+/K+-exchanging ATPase original-article Pediatric Surgery Pediatrics Phosphorylation Pre-eclampsia Preeclampsia Risk factors Sheep Tumor necrosis factor-α Vasoconstriction
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