Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice

With the advancement of age, skeletal muscle undergoes a progressive decline in mass, function, and regenerative capacity. Previously, our laboratory has reported an age-reduction in recovery and local induction of IGF-I gene expression with age following tourniquet (TK)-induced skeletal muscle isch...

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Veröffentlicht in:	Experimental gerontology 2011-04, Vol.46 (4), p.265-272
Hauptverfasser:	Hammers, David W., Matheny, Ronald W., Sell, Christian, Adamo, Martin L., Walters, Thomas J., Estep, J. Scot, Farrar, Roger P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Alternative Splicing Animals Base Sequence DNA Primers - genetics Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FoxO Gene Expression Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Male Mice Mice, Inbred C57BL mTOR Muscle regeneration Muscle, Skeletal - blood supply Muscle, Skeletal - injuries Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Proto-Oncogene Proteins c-akt - metabolism Reperfusion Injury - genetics Reperfusion Injury - metabolism Reperfusion Injury - pathology RNA, Messenger - genetics RNA, Messenger - metabolism Sarcopenia Sarcopenia - genetics Sarcopenia - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism Tourniquet
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