A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis

Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungun...

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Veröffentlicht in:	Vaccine 2011-03, Vol.29 (15), p.2803-2809
Hauptverfasser:	Wang, Danher, Suhrbier, Andreas, Penn-Nicholson, Adam, Woraratanadharm, Jan, Gardner, Joy, Luo, Min, Le, Thuy T, Anraku, Itaru, Sakalian, Michael, Einfeld, David, Dong, John Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Allergy and Immunology Alphavirus Alphavirus Infections - immunology Alphavirus Infections - prevention & control Animals antibodies Antibodies, Viral - blood Applied microbiology Arthritis Arthritis - immunology Arthritis - prevention & control Biological and medical sciences Chikungunya Chikungunya virus Chikungunya virus - genetics Chikungunya virus - immunology Drug Carriers Drug dosages Ebola virus Epidemics Female Fever Fundamental and applied biological sciences. Psychology Genetic Vectors Genomes Immunization Mice Mice, Inbred C57BL Microbiology Miscellaneous Monkeys & apes Mortality Rheumatic diseases Technological change Vaccination - methods Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Vector-borne diseases Viral Vaccines - administration & dosage Viral Vaccines - immunology viremia Viremia - immunology Viremia - prevention & control Virology Viruses
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