Identification of specificities of antibodies against human leukocyte antigens in blood donors

BACKGROUND: Transfusion‐related acute lung injury (TRALI) is the leading cause of transfusion‐related mortality. Blood centers are implementing TRALI risk reduction strategies based on screening apheresis donors for antibodies to human leukocyte antigens (HLA). STUDY DESIGN AND METHODS: HLA antibody...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2010-08, Vol.50 (8), p.1749-1760
Hauptverfasser:	Endres, Robert O., Kleinman, Steven H., Carrick, Danielle M., Steele, Whitney R., Wright, David J., Norris, Philip J., Triulzi, Darrell, Kakaiya, Ram, Busch, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - etiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibody Specificity Biological and medical sciences Blood Donors Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cross-Sectional Studies Female Fundamental and applied biological sciences. Psychology HLA Antigens - immunology Humans Isoantibodies - blood Male Medical sciences Pregnancy Prospective Studies Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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