Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes

Inhibition of bile acid (BA) transport may contribute to the hepatotoxicity of troglitazone (TRO), a peroxisome proliferator-activated receptor gamma agonist. Typically, studies use taurocholic acid (TCA) as a model substrate to investigate effects of xenobiotics on BA disposition. However, TRO may...

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Veröffentlicht in:	Toxicological sciences 2011-04, Vol.120 (2), p.371-380
Hauptverfasser:	Marion, Tracy L, Perry, Cassandra H, St Claire, 3rd, Robert L, Yue, Wei, Brouwer, Kim L R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics Biological Transport Carbon Radioisotopes Cells, Cultured Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chenodeoxycholic Acid - metabolism Chromans - toxicity Chromatography, High Pressure Liquid Hepatocytes - drug effects Hepatocytes - metabolism Male Methods and Alternatives to Animals PPAR gamma - agonists Propionates - pharmacology Quinolines - pharmacology Rats Rats, Wistar Tandem Mass Spectrometry Taurocholic Acid - metabolism Thiazolidinediones - toxicity
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