Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis

Severe halothane (HAL)-induced hepatotoxicity occurs in one in 6000-30,000 patients by an unknown mechanism. Female sex is a risk factor in humans and rodents. We tested the hypothesis that a sex difference in natural killer (NK) cell activity contributes to HAL-induced liver injury. HAL (15 mmol/kg...

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Veröffentlicht in:	Toxicological sciences 2011-04, Vol.120 (2), p.507-518
Hauptverfasser:	Dugan, Christine M, Fullerton, Aaron M, Roth, Robert A, Ganey, Patricia E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - toxicity Animals Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - immunology Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology Estrous Cycle Female Flow Cytometry Halothane - toxicity Hepatocytes - drug effects Hepatocytes - immunology Interferon-gamma - blood Interferon-gamma - genetics Killer Cells, Natural - immunology Lectins, C-Type - immunology Male Mice Mice, Inbred BALB C Mice, Knockout Ovariectomy Severity of Illness Index Sex Characteristics Systems Toxicology Toll-Like Receptor 4 - immunology
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