Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensi...

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Veröffentlicht in:	Cell metabolism 2011-02, Vol.13 (2), p.183-194
Hauptverfasser:	Scherer, Thomas, O'Hare, James, Diggs-Andrews, Kelly, Schweiger, Martina, Cheng, Bob, Lindtner, Claudia, Zielinski, Elizabeth, Vempati, Prashant, Su, Kai, Dighe, Shveta, Milsom, Thomas, Puchowicz, Michelle, Scheja, Ludger, Zechner, Rudolf, Fisher, Simon J., Previs, Stephen F., Buettner, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White - metabolism Animals Brain - metabolism Glucose - metabolism Insulin - metabolism Lipogenesis Lipolysis Male Mice Rats Rats, Sprague-Dawley Receptor, Insulin - metabolism Signal Transduction
Online-Zugang:	Volltext
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