β2-Adrenergic Receptor Signaling in Osteoblasts Contributes to the Catabolic Effect of Glucocorticoids on Bone

β2-Adrenergic receptor signaling in osteoblasts contributes to glucocorticoid-induced bone loss. The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-04, Vol.152 (4), p.1412-1422
Hauptverfasser:	Ma, Yun, Nyman, Jeffry S, Tao, Huan, Moss, Heather H, Yang, Xiangli, Elefteriou, Florent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Animals Animals, Newborn Autonomic nervous system Biological and medical sciences Blotting, Western Bone and Bones - drug effects Bone and Bones - metabolism Bone diseases Bone growth Bone loss Bone resorption Bone turnover Cell Differentiation Cell Line Cells, Cultured Cyclic AMP - metabolism Dexamethasone Dexamethasone - pharmacology Fundamental and applied biological sciences. Psychology Gene expression General Endocrinology Glucocorticoids Glucocorticoids - pharmacology Homeostasis Hormones Hypotheses In vivo methods and tests Inflammatory diseases Mice mRNA Nerves Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteogenesis Pharmacology Physiological effects Polymerase Chain Reaction Prednisolone Prednisolone - pharmacology Receptors (physiology) Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Signal Transduction - genetics Signal Transduction - physiology Sympathetic nerves Sympathetic nervous system Vertebrates: endocrinology X-Ray Microtomography
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