Murine Hematopoietic Cell Tissue Factor Pathway Inhibitor Limits Thrombus Growth

OBJECTIVE—Tissue factor (TF)–factor VIIa initiates blood coagulation and is found on microparticles that accumulate within intravascular thrombi. Tissue factor pathway inhibitor (TFPI), a factor Xa (fXa)–dependent inhibitor of TF–factor VIIa, is produced by megakaryocytes and is present in platelets...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-04, Vol.31 (4), p.821-826
Hauptverfasser:	Maroney, Susan A, Cooley, Brian C, Ferrel, Josephine P, Bonesho, Catherine E, Mast, Alan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Coagulation - genetics Blood Platelets - metabolism Blood vessels and receptors Blotting, Western Cardiology. Vascular system Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hepatocytes - metabolism Hepatocytes - transplantation Lipoproteins - deficiency Lipoproteins - genetics Lipoproteins - metabolism Liver - embryology Liver - metabolism Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Thrombosis - blood Thrombosis - genetics Thrombosis - prevention & control Time Factors Venous Thrombosis - blood Venous Thrombosis - genetics Venous Thrombosis - prevention & control Vertebrates: cardiovascular system Whole-Body Irradiation
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