Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also call...

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Veröffentlicht in:	Nature (London) 2010-12, Vol.468 (7324), p.653-658
Hauptverfasser:	Morrison, Sean J, Nakada, Daisuke, Saunders, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1542 631/67/581 631/80/641 631/80/642/333/1465 AMP-Activated Protein Kinases - chemistry AMP-Activated Protein Kinases - deficiency AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Aneuploidy Animals Bioenergetics Biological and medical sciences Catalytic Domain - genetics Cell cycle Cell Cycle - physiology Cell Death Cell differentiation, maturation, development, hematopoiesis Cell Division Cell physiology Cell Survival Centrosome - pathology Energy metabolism Energy Metabolism - physiology Enzyme Activation Female Fundamental and applied biological sciences. Psychology Gene Deletion Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humanities and Social Sciences Kinases Male Mechanistic Target of Rapamycin Complex 1 Metabolism Mice Mice, Inbred C57BL Mitochondria - metabolism Mitochondria - pathology Molecular and cellular biology multidisciplinary Multiprotein Complexes Oxidative stress Pancytopenia - genetics Properties Protein Serine-Threonine Kinases - deficiency Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins - metabolism Regeneration Science Science (multidisciplinary) Signal Transduction Sirolimus - pharmacology Spindle Apparatus - pathology Stem cells TOR Serine-Threonine Kinases - metabolism Tumor suppressor genes Tumors
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