Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variet...

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Veröffentlicht in:	FEBS letters 2008-10, Vol.582 (23-24), p.3396-3400
Hauptverfasser:	Sironi, Luigi, Mitro, Nico, Cimino, Mauro, Gelosa, Paolo, Guerrini, Uliano, Tremoli, Elena, Saez, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 Acute cerebral ischemia Animals ATP-binding cassette A1 Benzoates - therapeutic use Benzylamines - therapeutic use Brain Ischemia - complications Brain Ischemia - drug therapy Brain Ischemia - pathology Cerebral Infarction - etiology Cerebral Infarction - pathology Cerebral Infarction - prevention & control Disease Models, Animal DNA-Binding Proteins - agonists Experimental therapy Ligands liver X receptor Liver X Receptors LXR Magnetic Resonance Imaging Male MRI Neuroprotection Nuclear receptor Orphan Nuclear Receptors Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - agonists SREBP sterol regulated-element binding protein Transcriptional activator
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