The role of chalcones in suppression of NF-κB-mediated inflammation and cancer
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly...
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| Veröffentlicht in: | International immunopharmacology 2011-03, Vol.11 (3), p.295-309 |
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| creator | Yadav, Vivek R. Prasad, Sahdeo Sung, Bokyung Aggarwal, Bharat B. |
| description | Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2’,4’-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review. |
| doi_str_mv | 10.1016/j.intimp.2010.12.006 |
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Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2’,4’-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2010.12.006</identifier><identifier>PMID: 21184860</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Angiogenesis ; Antioxidants ; Apoptosis ; Aromatics ; Cancer ; Cereals ; Chalcone ; Chalcones - chemistry ; Chalcones - pharmacology ; Diabetes mellitus ; Fruits ; hops ; Humans ; Immune system ; Immunomodulation ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Invasion and angiogenesis ; ketones ; Malus ; Metastases ; Naringenin ; Neoplasms - prevention & control ; NF-kappa B - metabolism ; Nuclear factor-κB ; Reviews ; Spices ; Survival ; Tumor cell proliferation ; Tumorigenesis ; Vegetables</subject><ispartof>International immunopharmacology, 2011-03, Vol.11 (3), p.295-309</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-de8de084f7325f4b0415146de49f2ace7a4cb83e156506169c1ee658d2e1e80e3</citedby><cites>FETCH-LOGICAL-c494t-de8de084f7325f4b0415146de49f2ace7a4cb83e156506169c1ee658d2e1e80e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2010.12.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21184860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Vivek R.</creatorcontrib><creatorcontrib>Prasad, Sahdeo</creatorcontrib><creatorcontrib>Sung, Bokyung</creatorcontrib><creatorcontrib>Aggarwal, Bharat B.</creatorcontrib><title>The role of chalcones in suppression of NF-κB-mediated inflammation and cancer</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2’,4’-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review.</description><subject>Angiogenesis</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Aromatics</subject><subject>Cancer</subject><subject>Cereals</subject><subject>Chalcone</subject><subject>Chalcones - chemistry</subject><subject>Chalcones - pharmacology</subject><subject>Diabetes mellitus</subject><subject>Fruits</subject><subject>hops</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Invasion and angiogenesis</subject><subject>ketones</subject><subject>Malus</subject><subject>Metastases</subject><subject>Naringenin</subject><subject>Neoplasms - prevention & control</subject><subject>NF-kappa B - metabolism</subject><subject>Nuclear factor-κB</subject><subject>Reviews</subject><subject>Spices</subject><subject>Survival</subject><subject>Tumor cell proliferation</subject><subject>Tumorigenesis</subject><subject>Vegetables</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOxCAUJUbj-w-M6c5VR2iB0o2JGl-J0Y2uCQO3DpMWKnQm8df8CL9JmvG50RXknnPvPecehA4InhBM-PF8Yt1gu35S4LFUTDDma2ibiErkpMJsPf0Zr3JW8XoL7cQ4xzjVKdlEWwUhggqOt9H9wwyy4FvIfJPpmWq1dxAz67K46PsAMVrvRuzuMn97Pcs7MFYNYBKjaVXXqWHElTOZVk5D2EMbjWoj7H-8u-jx8uLh_Dq_vb-6OT-9zTWt6ZAbEAawoE1VFqyh0ySLEcoN0LoplIZKUT0VJSQHDHPCa00AOBOmAAICQ7mLTlZz-8U0adLghqBa2QfbqfAivbLyN-LsTD75pSwxE1yINODoY0DwzwuIg-xs1NC2yoFfRCl4zURdlvR_JqNlJUTFEpOumDr4GAM0X3oIlmNoci5XockxNEkKmUJLbYc_vXw1fab0bRbSRZcWgozaQjq3sQH0II23f294BwDxq9Y</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Yadav, Vivek R.</creator><creator>Prasad, Sahdeo</creator><creator>Sung, Bokyung</creator><creator>Aggarwal, Bharat B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>The role of chalcones in suppression of NF-κB-mediated inflammation and cancer</title><author>Yadav, Vivek R. ; 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| subjects | Angiogenesis Antioxidants Apoptosis Aromatics Cancer Cereals Chalcone Chalcones - chemistry Chalcones - pharmacology Diabetes mellitus Fruits hops Humans Immune system Immunomodulation Inflammation Inflammation - drug therapy Inflammation - metabolism Invasion and angiogenesis ketones Malus Metastases Naringenin Neoplasms - prevention & control NF-kappa B - metabolism Nuclear factor-κB Reviews Spices Survival Tumor cell proliferation Tumorigenesis Vegetables |
| title | The role of chalcones in suppression of NF-κB-mediated inflammation and cancer |
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