A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis
Phospholipase A 2 (PLA 2 ) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA 2 enzymes (sPLA 2 ), numbering nine members in humans, are poorly understood, though they have b...
Gespeichert in:
| Veröffentlicht in: | EMBO molecular medicine 2010-05, Vol.2 (5), p.172-187 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 187 |
|---|---|
| container_issue | 5 |
| container_start_page | 172 |
| container_title | EMBO molecular medicine |
| container_volume | 2 |
| creator | Boilard, Eric Lai, Ying Larabee, Katherine Balestrieri, Barbara Ghomashchi, Farideh Fujioka, Daisuke Gobezie, Reuben Coblyn, Jonathan S. Weinblatt, Michael E. Massarotti, Elena M. Thornhill, Thomas S. Divangahi, Maziar Remold, Heinz Lambeau, Gérard Gelb, Michael H. Arm, Jonathan P. Lee, David M. |
| description | Phospholipase A
2
(PLA
2
) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA
2
enzymes (sPLA
2
), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA
2
in disease, we quantified the expression of these enzymes in the synovial fluid in rheumatoid arthritis and used gene‐deleted mice to examine their contribution in a mouse model of autoimmune erosive inflammatory arthritis. Contrary to expectation, we find that the group V sPLA
2
isoform plays a novel anti‐inflammatory role that opposes the pro‐inflammatory activity of group IIA sPLA
2
. Mechanistically, group V sPLA
2
counter‐regulation includes promotion of immune complex clearance by regulating cysteinyl leukotriene synthesis. These observations identify a novel anti‐inflammatory function for a PLA
2
and identify group V sPLA
2
as a potential biotherapeutic for treatment of immune‐complex‐mediated inflammation. |
| doi_str_mv | 10.1002/emmm.201000072 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3058614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733316744</sourcerecordid><originalsourceid>FETCH-LOGICAL-h4102-f5f05c9ea3aeff35cf81aea9634f6a866e82e08869b33848d4c889c138db7e283</originalsourceid><addsrcrecordid>eNp1kctu1DAUhiMEoqWwZYm8Qyym9S2Os0EaVYUizYgNrC1P5rhx5Uuwkymz6yP0GXkSPEyJAImF5XP7Px_5r6rXBJ8TjOkFeO_PKS4xxg19Up2Spm4WXEj-dI4bcVK9yPkWY1ELIp9XJxRzRmvMTiuzRCHuwCEdRvvj_sEG47T3eoxpj1J0gExMKEOX4Fdp6GMux9lBZ0BLimxA1vspAOqiHxx8LxAPW6tH2CKdxj7Z0eaX1TOjXYZXj_dZ9fXD1ZfL68Xq88dPl8vVoucE04WpDa67FjTTYAyrOyOJBt0Kxo3QUgiQFLCUot0wJrnc8k7KtiNMbjcNUMnOqvdH7jBtyhYdhDFpp4ZkvU57FbVVf3eC7dVN3CmGaykIL4B3R0D_j-x6uVKHGsa8bQQjO1Jm3z4-luK3CfKovM0dOKcDxCmrhjFGRMMP1Dd_rjWDf_tQBtrjwJ11sJ_7BKuDy-rgsppdVlfr9XrOivbiqM1FFm4gqds4pVC--T969hNuFq6f</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733316744</pqid></control><display><type>article</type><title>A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Boilard, Eric ; Lai, Ying ; Larabee, Katherine ; Balestrieri, Barbara ; Ghomashchi, Farideh ; Fujioka, Daisuke ; Gobezie, Reuben ; Coblyn, Jonathan S. ; Weinblatt, Michael E. ; Massarotti, Elena M. ; Thornhill, Thomas S. ; Divangahi, Maziar ; Remold, Heinz ; Lambeau, Gérard ; Gelb, Michael H. ; Arm, Jonathan P. ; Lee, David M.</creator><creatorcontrib>Boilard, Eric ; Lai, Ying ; Larabee, Katherine ; Balestrieri, Barbara ; Ghomashchi, Farideh ; Fujioka, Daisuke ; Gobezie, Reuben ; Coblyn, Jonathan S. ; Weinblatt, Michael E. ; Massarotti, Elena M. ; Thornhill, Thomas S. ; Divangahi, Maziar ; Remold, Heinz ; Lambeau, Gérard ; Gelb, Michael H. ; Arm, Jonathan P. ; Lee, David M.</creatorcontrib><description>Phospholipase A
2
(PLA
2
) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA
2
enzymes (sPLA
2
), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA
2
in disease, we quantified the expression of these enzymes in the synovial fluid in rheumatoid arthritis and used gene‐deleted mice to examine their contribution in a mouse model of autoimmune erosive inflammatory arthritis. Contrary to expectation, we find that the group V sPLA
2
isoform plays a novel anti‐inflammatory role that opposes the pro‐inflammatory activity of group IIA sPLA
2
. Mechanistically, group V sPLA
2
counter‐regulation includes promotion of immune complex clearance by regulating cysteinyl leukotriene synthesis. These observations identify a novel anti‐inflammatory function for a PLA
2
and identify group V sPLA
2
as a potential biotherapeutic for treatment of immune‐complex‐mediated inflammation.</description><identifier>ISSN: 1757-4676</identifier><identifier>EISSN: 1757-4684</identifier><identifier>DOI: 10.1002/emmm.201000072</identifier><identifier>PMID: 20432503</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Anti-Inflammatory Agents - immunology ; Antigen-Antibody Complex - immunology ; arthritis ; Arthritis, Rheumatoid - enzymology ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; autoimmunity ; Disease Models, Animal ; Female ; Human health and pathology ; Humans ; inflammation ; Life Sciences ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Phospholipases A2, Secretory - genetics ; Phospholipases A2, Secretory - immunology ; Research Article ; secreted phospholipase A2 ; Synovial Fluid - enzymology ; Synovial Fluid - immunology</subject><ispartof>EMBO molecular medicine, 2010-05, Vol.2 (5), p.172-187</ispartof><rights>EMBO Molecular Medicine 2010</rights><rights>Copyright © 2010 EMBO Molecular Medicine</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2010 EMBO Molecular Medicine 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-6319-6432 ; 0000-0002-9239-518X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058614/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058614/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11560,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20432503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00497631$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boilard, Eric</creatorcontrib><creatorcontrib>Lai, Ying</creatorcontrib><creatorcontrib>Larabee, Katherine</creatorcontrib><creatorcontrib>Balestrieri, Barbara</creatorcontrib><creatorcontrib>Ghomashchi, Farideh</creatorcontrib><creatorcontrib>Fujioka, Daisuke</creatorcontrib><creatorcontrib>Gobezie, Reuben</creatorcontrib><creatorcontrib>Coblyn, Jonathan S.</creatorcontrib><creatorcontrib>Weinblatt, Michael E.</creatorcontrib><creatorcontrib>Massarotti, Elena M.</creatorcontrib><creatorcontrib>Thornhill, Thomas S.</creatorcontrib><creatorcontrib>Divangahi, Maziar</creatorcontrib><creatorcontrib>Remold, Heinz</creatorcontrib><creatorcontrib>Lambeau, Gérard</creatorcontrib><creatorcontrib>Gelb, Michael H.</creatorcontrib><creatorcontrib>Arm, Jonathan P.</creatorcontrib><creatorcontrib>Lee, David M.</creatorcontrib><title>A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis</title><title>EMBO molecular medicine</title><addtitle>EMBO Mol Med</addtitle><addtitle>EMBO Mol Med</addtitle><description>Phospholipase A
2
(PLA
2
) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA
2
enzymes (sPLA
2
), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA
2
in disease, we quantified the expression of these enzymes in the synovial fluid in rheumatoid arthritis and used gene‐deleted mice to examine their contribution in a mouse model of autoimmune erosive inflammatory arthritis. Contrary to expectation, we find that the group V sPLA
2
isoform plays a novel anti‐inflammatory role that opposes the pro‐inflammatory activity of group IIA sPLA
2
. Mechanistically, group V sPLA
2
counter‐regulation includes promotion of immune complex clearance by regulating cysteinyl leukotriene synthesis. These observations identify a novel anti‐inflammatory function for a PLA
2
and identify group V sPLA
2
as a potential biotherapeutic for treatment of immune‐complex‐mediated inflammation.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - immunology</subject><subject>Antigen-Antibody Complex - immunology</subject><subject>arthritis</subject><subject>Arthritis, Rheumatoid - enzymology</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>autoimmunity</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>inflammation</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Phospholipases A2, Secretory - genetics</subject><subject>Phospholipases A2, Secretory - immunology</subject><subject>Research Article</subject><subject>secreted phospholipase A2</subject><subject>Synovial Fluid - enzymology</subject><subject>Synovial Fluid - immunology</subject><issn>1757-4676</issn><issn>1757-4684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhiMEoqWwZYm8Qyym9S2Os0EaVYUizYgNrC1P5rhx5Uuwkymz6yP0GXkSPEyJAImF5XP7Px_5r6rXBJ8TjOkFeO_PKS4xxg19Up2Spm4WXEj-dI4bcVK9yPkWY1ELIp9XJxRzRmvMTiuzRCHuwCEdRvvj_sEG47T3eoxpj1J0gExMKEOX4Fdp6GMux9lBZ0BLimxA1vspAOqiHxx8LxAPW6tH2CKdxj7Z0eaX1TOjXYZXj_dZ9fXD1ZfL68Xq88dPl8vVoucE04WpDa67FjTTYAyrOyOJBt0Kxo3QUgiQFLCUot0wJrnc8k7KtiNMbjcNUMnOqvdH7jBtyhYdhDFpp4ZkvU57FbVVf3eC7dVN3CmGaykIL4B3R0D_j-x6uVKHGsa8bQQjO1Jm3z4-luK3CfKovM0dOKcDxCmrhjFGRMMP1Dd_rjWDf_tQBtrjwJ11sJ_7BKuDy-rgsppdVlfr9XrOivbiqM1FFm4gqds4pVC--T969hNuFq6f</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Boilard, Eric</creator><creator>Lai, Ying</creator><creator>Larabee, Katherine</creator><creator>Balestrieri, Barbara</creator><creator>Ghomashchi, Farideh</creator><creator>Fujioka, Daisuke</creator><creator>Gobezie, Reuben</creator><creator>Coblyn, Jonathan S.</creator><creator>Weinblatt, Michael E.</creator><creator>Massarotti, Elena M.</creator><creator>Thornhill, Thomas S.</creator><creator>Divangahi, Maziar</creator><creator>Remold, Heinz</creator><creator>Lambeau, Gérard</creator><creator>Gelb, Michael H.</creator><creator>Arm, Jonathan P.</creator><creator>Lee, David M.</creator><general>Nature Publishing Group UK</general><general>WILEY‐VCH Verlag</general><general>Wiley Open Access</general><general>WILEY-VCH Verlag</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6319-6432</orcidid><orcidid>https://orcid.org/0000-0002-9239-518X</orcidid></search><sort><creationdate>20100501</creationdate><title>A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis</title><author>Boilard, Eric ; Lai, Ying ; Larabee, Katherine ; Balestrieri, Barbara ; Ghomashchi, Farideh ; Fujioka, Daisuke ; Gobezie, Reuben ; Coblyn, Jonathan S. ; Weinblatt, Michael E. ; Massarotti, Elena M. ; Thornhill, Thomas S. ; Divangahi, Maziar ; Remold, Heinz ; Lambeau, Gérard ; Gelb, Michael H. ; Arm, Jonathan P. ; Lee, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h4102-f5f05c9ea3aeff35cf81aea9634f6a866e82e08869b33848d4c889c138db7e283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - immunology</topic><topic>Antigen-Antibody Complex - immunology</topic><topic>arthritis</topic><topic>Arthritis, Rheumatoid - enzymology</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>autoimmunity</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>inflammation</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Phospholipases A2, Secretory - genetics</topic><topic>Phospholipases A2, Secretory - immunology</topic><topic>Research Article</topic><topic>secreted phospholipase A2</topic><topic>Synovial Fluid - enzymology</topic><topic>Synovial Fluid - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boilard, Eric</creatorcontrib><creatorcontrib>Lai, Ying</creatorcontrib><creatorcontrib>Larabee, Katherine</creatorcontrib><creatorcontrib>Balestrieri, Barbara</creatorcontrib><creatorcontrib>Ghomashchi, Farideh</creatorcontrib><creatorcontrib>Fujioka, Daisuke</creatorcontrib><creatorcontrib>Gobezie, Reuben</creatorcontrib><creatorcontrib>Coblyn, Jonathan S.</creatorcontrib><creatorcontrib>Weinblatt, Michael E.</creatorcontrib><creatorcontrib>Massarotti, Elena M.</creatorcontrib><creatorcontrib>Thornhill, Thomas S.</creatorcontrib><creatorcontrib>Divangahi, Maziar</creatorcontrib><creatorcontrib>Remold, Heinz</creatorcontrib><creatorcontrib>Lambeau, Gérard</creatorcontrib><creatorcontrib>Gelb, Michael H.</creatorcontrib><creatorcontrib>Arm, Jonathan P.</creatorcontrib><creatorcontrib>Lee, David M.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boilard, Eric</au><au>Lai, Ying</au><au>Larabee, Katherine</au><au>Balestrieri, Barbara</au><au>Ghomashchi, Farideh</au><au>Fujioka, Daisuke</au><au>Gobezie, Reuben</au><au>Coblyn, Jonathan S.</au><au>Weinblatt, Michael E.</au><au>Massarotti, Elena M.</au><au>Thornhill, Thomas S.</au><au>Divangahi, Maziar</au><au>Remold, Heinz</au><au>Lambeau, Gérard</au><au>Gelb, Michael H.</au><au>Arm, Jonathan P.</au><au>Lee, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis</atitle><jtitle>EMBO molecular medicine</jtitle><stitle>EMBO Mol Med</stitle><addtitle>EMBO Mol Med</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>2</volume><issue>5</issue><spage>172</spage><epage>187</epage><pages>172-187</pages><issn>1757-4676</issn><eissn>1757-4684</eissn><abstract>Phospholipase A
2
(PLA
2
) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA
2
enzymes (sPLA
2
), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA
2
in disease, we quantified the expression of these enzymes in the synovial fluid in rheumatoid arthritis and used gene‐deleted mice to examine their contribution in a mouse model of autoimmune erosive inflammatory arthritis. Contrary to expectation, we find that the group V sPLA
2
isoform plays a novel anti‐inflammatory role that opposes the pro‐inflammatory activity of group IIA sPLA
2
. Mechanistically, group V sPLA
2
counter‐regulation includes promotion of immune complex clearance by regulating cysteinyl leukotriene synthesis. These observations identify a novel anti‐inflammatory function for a PLA
2
and identify group V sPLA
2
as a potential biotherapeutic for treatment of immune‐complex‐mediated inflammation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20432503</pmid><doi>10.1002/emmm.201000072</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-6319-6432</orcidid><orcidid>https://orcid.org/0000-0002-9239-518X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1757-4676 |
| ispartof | EMBO molecular medicine, 2010-05, Vol.2 (5), p.172-187 |
| issn | 1757-4676 1757-4684 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3058614 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Animals Anti-Inflammatory Agents - immunology Antigen-Antibody Complex - immunology arthritis Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology autoimmunity Disease Models, Animal Female Human health and pathology Humans inflammation Life Sciences Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Phospholipases A2, Secretory - genetics Phospholipases A2, Secretory - immunology Research Article secreted phospholipase A2 Synovial Fluid - enzymology Synovial Fluid - immunology |
| title | A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T13%3A13%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20anti%E2%80%90inflammatory%20role%20for%20secretory%20phospholipase%20A2%20in%20immune%20complex%E2%80%90mediated%20arthritis&rft.jtitle=EMBO%20molecular%20medicine&rft.au=Boilard,%20Eric&rft.date=2010-05-01&rft.volume=2&rft.issue=5&rft.spage=172&rft.epage=187&rft.pages=172-187&rft.issn=1757-4676&rft.eissn=1757-4684&rft_id=info:doi/10.1002/emmm.201000072&rft_dat=%3Cproquest_pubme%3E733316744%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733316744&rft_id=info:pmid/20432503&rfr_iscdi=true |