ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

XLF, ATM and H2AX share role in joining DNA breaks The loss of a classical non-homologous end-joining (NHEJ) repair factor, XLF, shows strong effects in non-lymphoid cells, but in lymphoid cells its absence surprisingly has only modest effects on V(D)J recombination. Frederick Alt and colleagues sho...

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Veröffentlicht in:	Nature (London) 2011-01, Vol.469 (7329), p.250-254
Hauptverfasser:	Zha, Shan, Guo, Chunguang, Boboila, Cristian, Oksenych, Valentyn, Cheng, Hwei-Ling, Zhang, Yu, Wesemann, Duane R., Yuen, Grace, Patel, Harin, Goff, Peter H., Dubois, Richard L., Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619 631/250/2152/2497 631/337/1427/2122 631/337/1427/2191 Animals Ataxia telangiectasia Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Care and treatment Causes of Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Transformed Chromatin - metabolism Chromosomes, Mammalian - genetics Chromosomes, Mammalian - metabolism Deoxyribonucleic acid Diagnosis DNA DNA Breaks, Double-Stranded DNA damage DNA Repair DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Fundamental and applied biological sciences. Psychology Gene Rearrangement, B-Lymphocyte - genetics Histones - metabolism Humanities and Social Sciences Immunology Inactivation Kinases letter Lymphocytes Mice Molecular and cellular biology Molecular genetics multidisciplinary Mutagenesis. Repair Precursor Cells, B-Lymphoid - cytology Precursor Cells, B-Lymphoid - metabolism Protein Serine-Threonine Kinases - deficiency Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Recombination, Genetic Science Science (multidisciplinary) T cell receptors Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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