Evaluation of Alkyne‐Modified Isoprenoids as Chemical Reporters of Protein Prenylation

Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific sequences localized at or near the C‐termini of specific proteins. Determination of the specific protein prenyltransferase substrates affected by the inhibition of these enzym...

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Veröffentlicht in:	Chemical biology & drug design 2010-12, Vol.76 (6), p.460-471
Hauptverfasser:	DeGraw, Amanda J, Palsuledesai, Charuta, Ochocki, Joshua D, Dozier, Jonathan K, Lenevich, Stepan, Rashidian, Mohammad, Distefano, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Animals Azides - chemistry Biomarkers - chemistry Catalytic Domain Cell Line chemical proteomics click reaction Electrophoresis, Gel, Two-Dimensional farnesyl diphosphate HeLa Cells Humans prenylome prenyltransferase Protein Prenylation protein profiling Proteomics - methods Quantum Theory Substrate Specificity Terpenes - chemistry
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