Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABAA receptors in vitro

BACKGROUND AND PURPOSE Flavonoids, important plant pigments, have been shown to allosterically modulate brain GABAA receptors (GABAARs). We previously reported that trans‐6,4′‐dimethoxyretrochalcone (Rc‐OMe), a hydrolytic derivative of the corresponding flavylium salt, displayed nanomolar affinity f...

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Veröffentlicht in:	British journal of pharmacology 2011-03, Vol.162 (6), p.1326-1339
Hauptverfasser:	Jiang, Ruotian, Miyamoto, Akiko, Martz, Adeline, Specht, Alexandre, Ishibashi, Hitoshi, Kueny‐Stotz, Marie, Chassaing, Stefan, Brouillard, Raymond, de Carvalho, Lia Prado, Goeldner, Maurice, Nabekura, Junichi, Nielsen, Mogens, Grutter, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric modulators Binding sites Biological and medical sciences Derivatives flavylium salts GABAA ion channels Medical research Medical sciences Pharmacology. Drug treatments Research Papers Rodents trans‐retrochalcones
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