Anti‐angiogenic effects of two cystine‐knot miniproteins from tomato fruit

BACKGROUND AND PURPOSE Cystine‐knot miniproteins are characterized by a similar molecular structure. Some cystine‐knot miniproteins display therapeutically useful biological activities, as antithrombotic agents or tumour growth inhibitors. A critical event in the progression of tumours is the format...

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Veröffentlicht in:	British journal of pharmacology 2011-03, Vol.162 (6), p.1261-1273
Hauptverfasser:	Cavallini, C, Trettene, M, Degan, M, Delva, P, Molesini, B, Minuz, P, Pandolfini, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Biological and medical sciences Cell Line Cell Migration Assays Cell Proliferation - drug effects Cell Survival - drug effects Cystine-Knot Miniproteins - chemistry Cystine-Knot Miniproteins - pharmacology cystine‐knot miniproteins Endothelial Cells - drug effects Fruit Humans Kinases Lycopersicon esculentum - chemistry MAPK pathway Medical sciences Mitogen-Activated Protein Kinase 1 - analysis Neovascularization, Pathologic - drug therapy Pharmacology. Drug treatments Phosphorylation Receptor, Epidermal Growth Factor - analysis Recombinant Proteins - chemistry Recombinant Proteins - pharmacology Research Papers Signal Transduction - drug effects tomato fruit
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