Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4

Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu4, a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase par...

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Veröffentlicht in:	ACS combinatorial science 2011-03, Vol.13 (2), p.159-165
Hauptverfasser:	Cheung, Yiu-Yin, Zamorano, Rocio, Blobaum, Anna L, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R
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container_title	ACS combinatorial science
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creator	Cheung, Yiu-Yin Zamorano, Rocio Blobaum, Anna L Weaver, C. David Conn, P. Jeffrey Lindsley, Craig W Niswender, Colleen M Hopkins, Corey R
description	Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu4, a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu4 provide critical research tools to further probe the mGlu4-mediated effects in Parkinson’s disease.
doi_str_mv	10.1021/co1000508
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title	Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4
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