Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice

Accumulation of plasma cells and autoantibodies against nuclear antigens characterize both human and murine lupus. Understanding how these processes are controlled may reveal novel therapeutic targets for this disease. Mice deficient in Lyn, a negative regulator of B and myeloid cell activity, devel...

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Veröffentlicht in:European journal of immunology 2010-07, Vol.40 (7), p.1897-1905
Hauptverfasser: Gutierrez, Toni, Halcomb, Kristina E, Coughran, Alanna J, Li, Quan-Zhen, Satterthwaite, Anne B
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Sprache:eng
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