Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast

The biogenesis of a number of RNA species in eukaryotic cells requires 3′ processing. To determine the enzymes responsible for these trimming events, we created yeast strains lacking specific 3′ to 5′ exonucleases. In this work, we describe the analysis of three members of the RNase D family of exon...

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Veröffentlicht in:	The EMBO journal 2000-03, Vol.19 (6), p.1357-1365
Hauptverfasser:	Van Hoof, A, Lennertz, P, Parker, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Conserved Sequence - genetics Endoribonucleases - genetics Endoribonucleases - metabolism enzyme activity exonuclease exonucleases Gene Deletion Genes, Fungal - genetics Genes, Fungal - physiology maturation MRP RNA processing Rex1 protein Rex1p protein Rex2 protein Rex2p protein Rex3 protein Rex3p protein ribonuclease D Ribonuclease III ribonuclease MRP Ribonuclease P ribonucleases Ribonucleases - genetics Ribonucleases - metabolism ribosomal RNA RNA rna maturation rna processing RNA Processing, Post-Transcriptional - genetics RNA Stability RNA, Catalytic - genetics RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Ribosomal - genetics RNA, Ribosomal - metabolism RNA, Ribosomal, 5.8S - genetics RNA, Ribosomal, 5.8S - metabolism RNA, Ribosomal, 5S - genetics RNA, Ribosomal, 5S - metabolism RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism RNA, Transfer, Arg - genetics RNA, Transfer, Arg - metabolism rRNA 5S Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins small nuclear RNA snRNA U4 snRNA U5 Substrate Specificity Yeasts
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