Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes

Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surr...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2010-10, Vol.330 (6002), p.366-369
Hauptverfasser:	Zhang, Meijia, Su, You-Qiang, Sugiura, Koji, Xia, Guoliang, Eppig, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animals Biochemistry Biological and medical sciences Cell division Cumulus Cells - metabolism Cyclic AMP - metabolism Cyclic GMP - metabolism Female Follicles Fundamental and applied biological sciences. Psychology Germ cells Granulosa cells Granulosa Cells - metabolism Intercellular Signaling Peptides and Proteins - metabolism Ligands Mammalian female genital system Meiosis Messenger RNA Mice Models, Biological Morphology. Physiology Murals Mutation Natriuretic Peptide, C-Type - genetics Natriuretic Peptide, C-Type - metabolism Oocytes Oocytes - physiology Ovarian Follicle - cytology Ovaries Peptides Protein Precursors - genetics Protein Precursors - metabolism Receptors Receptors, Atrial Natriuretic Factor - genetics Receptors, Atrial Natriuretic Factor - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal Transduction Somatic cells Vertebrates: reproduction
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