Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination

The mechanisms underlying oligodendrocyte (OLG) loss and the precise roles played by OLG death in human demyelinating diseases such as multiple sclerosis (MS), and in the rodent model of MS, experimental autoimmune encephalomyelitis (EAE), remain to be elucidated. To clarify the involvement of OLG d...

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Veröffentlicht in:	The EMBO journal 2000-02, Vol.19 (3), p.341-348
Hauptverfasser:	Hisahara, Shin, Araki, Takashi, Sugiyama, Fumihiro, Yagami, Ken-ichi, Suzuki, Misao, Abe, Kuniya, Yamamura, Ken-ichi, Miyazaki, Jun-ichi, Momoi, Takashi, Saruta, Takao, Bernard, Claude C. A., Okano, Hideyuki, Miura, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Baculovirus baculovirus p35 caspase Caspase Inhibitors caspase-3 Demyelinating Autoimmune Diseases, CNS - metabolism Demyelinating Autoimmune Diseases, CNS - prevention & control demyelination Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Enzyme Inhibitors - metabolism fas Receptor - pharmacology Gene Expression Gene Targeting Immunization Immunohistochemistry Inhibitor of Apoptosis Proteins Interferon-gamma - pharmacology Mice Mice, Transgenic Mortality Myelin Proteins Myelin-Associated Glycoprotein - immunology Myelin-Oligodendrocyte Glycoprotein oligodendrocyte oligodendrocytes Oligodendroglia - metabolism p35 protein RNA, Messenger - metabolism Spinal Cord - metabolism Tumor Necrosis Factor-alpha - pharmacology Viral Proteins - genetics
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