Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the α 7 nicotinic acetylcholine receptor and, possibly, the glycine co-agonist site of the NMDA receptor. The functions of these two receptors, which are intimately involved in synaptic plasticity...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2010-07, Vol.35 (8), p.1734-1742
Hauptverfasser:	Potter, Michelle C, Elmer, Greg I, Bergeron, Richard, Albuquerque, Edson X, Guidetti, Paolo, Wu, Hui-Qiu, Schwarcz, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1595/1554 631/378/2591 631/378/2649 631/45/882 Adult and adolescent clinical studies Animals Animals, Newborn Avoidance Learning - physiology Behavioral Sciences Biological and medical sciences Biological Psychology Cognition - physiology Discrimination (Psychology) - physiology Exploratory Behavior - physiology Extracellular Fluid - metabolism Glutamic Acid - metabolism Hippocampus - cytology Hippocampus - physiology In Vitro Techniques Kynurenic Acid - metabolism Long-Term Potentiation - genetics Long-Term Potentiation - physiology Maze Learning - physiology Medical sciences Medicine Medicine & Public Health Mice Mice, Knockout Microdialysis - methods Neuropsychological Tests Neurosciences Original original-article Patch-Clamp Techniques Pharmacotherapy Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Recognition (Psychology) - physiology Schizophrenia Transaminases - deficiency
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