Redox compartmentalization and cellular stress

Mammalian cells are highly organized to optimize function. For instance, oxidative energy-producing processes in mitochondria are sequestered away from plasma membrane redox signalling complexes and also from nuclear DNA, which is subject to oxidant-induced mutation. Proteins are unique among macrom...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2010-10, Vol.12 (s2), p.116-125
Hauptverfasser:	Jones, D.P, Go, Y.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Cell Compartmentation - drug effects Cell Compartmentation - physiology Cellular stress response Control systems cysteine diabetes mellitus Glutathione Humans Mammalian cells Metabolism Mitochondria - physiology Organelles Oxidants Oxidation Oxidation-Reduction - drug effects oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology prevention Protein Disulfide Reductase (Glutathione) - blood Protein Disulfide Reductase (Glutathione) - physiology Proteins redox signalling Signal Transduction - drug effects Stress Structure-function relationships Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - physiology Thioredoxin vulnerability
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