Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology
AIM： To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS： Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 a...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2011-02, Vol.17 (7), p.922-925 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Malham, Mikkel Jørgensen, Søren Peter Ott, Peter Agnholt, Jørgen Vilstrup, Hendrik Borre, Mette Dahlerup, Jens F |
| description | AIM： To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS： Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS： Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively （P 0.001）. In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION： Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. |
| doi_str_mv | 10.3748/wjg.v17.i7.922 |
| format | Article |
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METHODS： Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS： Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively （P 0.001）. In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION： Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v17.i7.922</identifier><identifier>PMID: 21412501</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Brief ; Humans ; Liver - physiopathology ; Liver Cirrhosis, Alcoholic - blood ; Liver Cirrhosis, Alcoholic - complications ; Liver Cirrhosis, Alcoholic - physiopathology ; Liver Cirrhosis, Biliary - blood ; Liver Cirrhosis, Biliary - complications ; Liver Cirrhosis, Biliary - physiopathology ; Prevalence ; Retrospective Studies ; Risk Factors ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology ; 严重程度 ; 原发性 ; 病因 ; 维生素D缺乏 ; 肝功能 ; 肝硬化 ; 肝脏疾病 ; 酒精性</subject><ispartof>World journal of gastroenterology : WJG, 2011-02, Vol.17 (7), p.922-925</ispartof><rights>2011 Baishideng Publishing Group Co., Limited. All rights reserved. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-429c94ece0a2c16d22203fc714506a66ceed4be3e80ec65c9d7caf0d486cab783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051142/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051142/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21412501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malham, Mikkel</creatorcontrib><creatorcontrib>Jørgensen, Søren Peter</creatorcontrib><creatorcontrib>Ott, Peter</creatorcontrib><creatorcontrib>Agnholt, Jørgen</creatorcontrib><creatorcontrib>Vilstrup, Hendrik</creatorcontrib><creatorcontrib>Borre, Mette</creatorcontrib><creatorcontrib>Dahlerup, Jens F</creatorcontrib><title>Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS： Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS： Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively （P 0.001）. In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION： Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.</description><subject>Brief</subject><subject>Humans</subject><subject>Liver - physiopathology</subject><subject>Liver Cirrhosis, Alcoholic - blood</subject><subject>Liver Cirrhosis, Alcoholic - complications</subject><subject>Liver Cirrhosis, Alcoholic - physiopathology</subject><subject>Liver Cirrhosis, Biliary - blood</subject><subject>Liver Cirrhosis, Biliary - complications</subject><subject>Liver Cirrhosis, Biliary - physiopathology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - etiology</subject><subject>严重程度</subject><subject>原发性</subject><subject>病因</subject><subject>维生素D缺乏</subject><subject>肝功能</subject><subject>肝硬化</subject><subject>肝脏疾病</subject><subject>酒精性</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LxDAQhoMoun5cPUr8Aa3JJG3aiyB-g-BFvYZsOm0j3VSTurL_3ojroqdhZt73neEh5JizXChZnX2-dvmSq9ypvAbYIjMAXmdQSbZNZpwxldUC1B7Zj_GVMRCigF2yB1xyKBifkacXN5mF8_SKNtg669DbFU29dSH0Y3SRBhzMhJFOIx3cEgNtVrH98HZyo6fBTH0aTb3x1GAaDWO3OiQ7rRkiHq3rAXm-uX66vMseHm_vLy8eMit5MWUSaltLtMgMWF42AMBEaxWXBStNWVrERs5RYMXQloWtG2VNyxpZldbMVSUOyPlP7tvHfIGNRT8FM-i34BYmrPRonP6_8a7X3bjUghWcS0gB-U-ADWOMAduNlzP9zVcnvjrx1U7pxDcZTv5e3Mh_gSbB6TqxH3337ny30QhVlcDT21-fGoYQ</recordid><startdate>20110221</startdate><enddate>20110221</enddate><creator>Malham, Mikkel</creator><creator>Jørgensen, Søren Peter</creator><creator>Ott, Peter</creator><creator>Agnholt, Jørgen</creator><creator>Vilstrup, Hendrik</creator><creator>Borre, Mette</creator><creator>Dahlerup, Jens F</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110221</creationdate><title>Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology</title><author>Malham, Mikkel ; Jørgensen, Søren Peter ; Ott, Peter ; Agnholt, Jørgen ; Vilstrup, Hendrik ; Borre, Mette ; Dahlerup, Jens F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-429c94ece0a2c16d22203fc714506a66ceed4be3e80ec65c9d7caf0d486cab783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Brief</topic><topic>Humans</topic><topic>Liver - physiopathology</topic><topic>Liver Cirrhosis, Alcoholic - blood</topic><topic>Liver Cirrhosis, Alcoholic - complications</topic><topic>Liver Cirrhosis, Alcoholic - physiopathology</topic><topic>Liver Cirrhosis, Biliary - blood</topic><topic>Liver Cirrhosis, Biliary - complications</topic><topic>Liver Cirrhosis, Biliary - physiopathology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><topic>严重程度</topic><topic>原发性</topic><topic>病因</topic><topic>维生素D缺乏</topic><topic>肝功能</topic><topic>肝硬化</topic><topic>肝脏疾病</topic><topic>酒精性</topic><toplevel>online_resources</toplevel><creatorcontrib>Malham, Mikkel</creatorcontrib><creatorcontrib>Jørgensen, Søren Peter</creatorcontrib><creatorcontrib>Ott, Peter</creatorcontrib><creatorcontrib>Agnholt, Jørgen</creatorcontrib><creatorcontrib>Vilstrup, Hendrik</creatorcontrib><creatorcontrib>Borre, Mette</creatorcontrib><creatorcontrib>Dahlerup, Jens F</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malham, Mikkel</au><au>Jørgensen, Søren Peter</au><au>Ott, Peter</au><au>Agnholt, Jørgen</au><au>Vilstrup, Hendrik</au><au>Borre, Mette</au><au>Dahlerup, Jens F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2011-02-21</date><risdate>2011</risdate><volume>17</volume><issue>7</issue><spage>922</spage><epage>925</epage><pages>922-925</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. 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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Brief Humans Liver - physiopathology Liver Cirrhosis, Alcoholic - blood Liver Cirrhosis, Alcoholic - complications Liver Cirrhosis, Alcoholic - physiopathology Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - physiopathology Prevalence Retrospective Studies Risk Factors Vitamin D - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - etiology 严重程度 原发性 病因 维生素D缺乏 肝功能 肝硬化 肝脏疾病 酒精性 |
| title | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology |
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