The role of hypoxia-inducible factors in tumorigenesis

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF- α ) and a constitutive beta subunit (HIF- β ) that facilitate both oxygen delivery and adaptation to o...

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Veröffentlicht in:	Cell death and differentiation 2008-04, Vol.15 (4), p.678-685
Hauptverfasser:	Rankin, E B, Giaccia, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Angiogenesis Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - metabolism Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell death Cell Differentiation Cell growth Cell Hypoxia Cell Proliferation Energy Metabolism Gene expression Humans Hydrocarbons Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Life Sciences Metabolism Neoplasm Invasiveness Neoplasm Metastasis Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy Neovascularization, Pathologic - metabolism Oncology Oxygen - metabolism Proteins Radiation review Signal Transduction Stem Cells Transcription factors Tumorigenesis
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