Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

Oxidative stress resulting from mitochondrially derived reactive oxygen species (ROS) has been hypothesized to damage mitochondrial oxidative phosphorylation (OXPHOS) and to be a factor in aging and degenerative disease. If this hypothesis is correct, then genetically inactivating potential mitochon...

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Veröffentlicht in:	Free radical biology & medicine 2000-03, Vol.28 (5), p.754-766
Hauptverfasser:	Esposito, Luke A., Kokoszka, Jason E., Waymire, Katrina G., Cottrell, Barbara, MacGregor, Grant R., Wallace, Douglas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence DNA Primers - genetics Female Free radicals Free Radicals - metabolism Glutathione peroxidase Glutathione Peroxidase - deficiency Glutathione Peroxidase - genetics Hydrogen peroxide Hydrogen Peroxide - metabolism In Vitro Techniques Knockout mice Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - enzymology Mitochondria - metabolism Mitochondria, Heart - metabolism Mitochondria, Liver - metabolism Oxidative phosphorylation Oxidative Stress Oxygen Consumption Pregnancy
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