Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity

Background: Advanced biliary cancer is often treated with fluoropyrimidine-based chemotherapy. In this study, we evaluated the efficacy and tolerability of a combination of S-1, an oral fluoropyrimidine prodrug, and oxaliplatin in patients with metastatic biliary cancer. Methods: Patients with histo...

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Veröffentlicht in:	British journal of cancer 2011-02, Vol.104 (4), p.605-612
Hauptverfasser:	Kim, K-p, Jang, G, Hong, Y S, Lim, H-S, Bae, K-s, Kim, H-S, Lee, S S, Shin, J-G, Lee, J-L, Ryu, M-H, Chang, H-M, Kang, Y-K, Kim, T W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/108 631/92/436/434 692/699/67/1504/1329 692/700/565/1436/1437 Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - genetics Biliary Tract Neoplasms - metabolism Biliary Tract Neoplasms - pathology Biomarkers, Pharmacological - analysis Biomarkers, Pharmacological - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - physiology Biomedical and Life Sciences Biomedicine Cancer Research Clinical Study Cytochrome P-450 CYP2A6 Drug Combinations Drug Resistance Epidemiology Female Humans Inactivation, Metabolic - genetics Inactivation, Metabolic - physiology Male Middle Aged Molecular Medicine Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Organoplatinum Compounds - pharmacokinetics Oxonic Acid - administration & dosage Oxonic Acid - adverse effects Oxonic Acid - pharmacokinetics Polymorphism, Single Nucleotide - physiology Tegafur - administration & dosage Tegafur - adverse effects Tegafur - pharmacokinetics Treatment Outcome Young Adult
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