Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries

Inflammation has an important function in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH); however, the mediators of this inflammatory response have not been clearly identified. In this study, we have investigated the potential function of two sphingolipids, which occur nat...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2011-01, Vol.31 (1), p.212-221
Hauptverfasser:	Wirrig, Christiane, Hunter, Irene, Mathieson, Fiona A, Nixon, Graeme F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Platelets - metabolism Blotting, Western Cells, Cultured Cerebral Arteries - metabolism Cerebral Arteries - pathology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Chemokine CCL2 - biosynthesis Electrophoretic Mobility Shift Assay Enzyme Activation - physiology Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Inflammation - chemically induced Inflammation - pathology Inflammation Mediators - physiology Lysophospholipids - metabolism Male Medical sciences Muscle, Smooth, Vascular - pathology Neurology NF-kappa B - metabolism Original p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylcholine - analogs & derivatives Phosphorylcholine - metabolism Rats Rats, Sprague-Dawley Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - physiology Subarachnoid Hemorrhage - pathology Transcription Factors - genetics Up-Regulation Vascular diseases and vascular malformations of the nervous system Vasospasm, Intracranial - pathology Vertebrates: nervous system and sense organs
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