Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis

Background. Patients with diabetes mellitus are more prone to bacterial sepsis, but there are conflicting data on whether outcomes are worse in diabetics after presentation with sepsis. Glyburide is an oral hypoglycemic agent used to treat diabetes mellitus. This K ATP -channel blocker and broad-spe...

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Veröffentlicht in:	Clinical infectious diseases 2011-03, Vol.52 (6), p.717-725
Hauptverfasser:	Koh, Gavin C. K. W., Maude, Rapeephan R., Schreiber, M. Fernanda, Limmathurotsakul, Direk, Wiersinga, W. Joost, Wuthiekanun, Vanaporn, Lee, Sue J., Mahavanakul, Weera, Chaowagul, Wipada, Chierakul, Wirongrong, White, Nicholas J., van der Poll, Tom, Day, Nicholas P. J., Dougan, Gordon, Peacock, Sharon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adult and Commentaries Anti-Inflammatory Agents - administration & dosage Antiinflammatories ARTICLES AND COMMENTARIES Bacterial diseases Biological and medical sciences Burkholderia pseudomallei - isolation & purification Cohort Studies Correlation analysis Diabetes Diabetes complications Female Gene expression Glyburide - administration & dosage Gram-negative bacteria Hospital admissions Human bacterial diseases Humans Immune system Infections Infectious diseases Leukocytes Male Medical sciences Melioidosis Melioidosis - drug therapy Melioidosis - mortality Middle Aged Mortality Neutrophils Prospective Studies Sepsis Sepsis - drug therapy Sepsis - microbiology Sepsis - mortality Survival Analysis Treatment Outcome Tropical bacterial diseases Type 2 diabetes mellitus
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