Inhibition of the Inflammatory Cytokine TNF-α Increases Adenovirus Activity in Ovarian Cancer via Modulation of cIAP1/2 Expression

Oncolytic adenoviruses show promise as a cancer treatment. However, they generate acute inflammatory responses with production of cytokines, including tumor necrosis factor-α (TNF-α). We investigated whether inhibition of TNF-α augments efficacy of the E1A CR2-deleted adenovirus dl922-947 in ovarian...

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Veröffentlicht in:	Molecular therapy 2011-03, Vol.19 (3), p.490-499
Hauptverfasser:	Salako, Michael A, Kulbe, Hagen, Ingemarsdotter, Carin K, Pirlo, Katrina J, Williams, Sarah L, Lockley, Michelle, Balkwill, Frances R, McNeish, Iain A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - drug effects Adenoviridae - immunology Adenoviridae - metabolism Adenovirus Animals Antibodies, Monoclonal - pharmacology Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Female Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques Humans Infliximab Inhibitor of Apoptosis Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude Oncolytic Virotherapy Oncolytic Viruses - drug effects Oncolytic Viruses - immunology Oncolytic Viruses - metabolism Original Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovarian Neoplasms - virology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Survival Analysis Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Virus Replication - drug effects Xenograft Model Antitumor Assays
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