Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights

► AKR1C3 produces steroids and prostaglandins for receptor mediated growth. ► AKR1C3 inhibition is desirable for hormone dependent and independent cancers. ► NSAIDs, steroids, flavonoids, cyclopentanes, and benzodiazepines inhibit AKR1C3. ► Crystal structures identify subpockets for rational design...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2011-05, Vol.125 (1), p.95-104
Hauptverfasser:	Byrns, Michael C., Jin, Yi, Penning, Trevor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 3-Hydroxysteroid Dehydrogenases - chemistry 3-Hydroxysteroid Dehydrogenases - metabolism Aldo-Keto Reductase Family 1 Member C3 Aldo–keto reductase Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Humans Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors Hydroxyprostaglandin Dehydrogenases - chemistry Hydroxyprostaglandin Dehydrogenases - metabolism Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Molecular Structure Neoplasms - enzymology Nuclear receptors Prostaglandins Steroid hormones Steroids - chemistry Steroids - metabolism Structure-based inhibitor design
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!