CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice

Background. Regulatory T cells (known as “Treg”) express apyrases (CD39) and ecto-5'-nucleotidase (CD73) and contribute to their inhibitory function by generating adenosine. We investigated the expression of CD39 and CD73 on human T helper (Th) cells and the role of CD73 in regulating Helicobac...

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Veröffentlicht in:	The Journal of infectious diseases 2009-02, Vol.199 (4), p.494-504
Hauptverfasser:	Alam, Mohammad S., Kurtz, Courtney C., Rowlett, Robert M., Reuter, Brian K., Wiznerowicz, Elizabeth, Das, Soumita, Linden, Joel, Crowe, Sheila E., Ernst, Peter B.
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - genetics 5'-Nucleotidase - metabolism Adenosine - metabolism Animals Antigens, CD - genetics Antigens, CD - metabolism Apyrase - genetics Apyrase - metabolism Bacteria Bacteriology Biological and medical sciences Blood Cell Proliferation Cells, Cultured Cytokines Cytokines - genetics Cytokines - metabolism Felis Flow Cytometry Fundamental and applied biological sciences. Psychology Gastric Mucosa - cytology Gastric Mucosa - immunology Gastritis Gastritis - genetics Gastritis - immunology Helicobacter Helicobacter felis Helicobacter Infections - genetics Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter pylori Humans Infections Infectious diseases Inflammation Interferon-gamma - genetics Interferon-gamma - metabolism Medical sciences Mice Mice, Inbred C57BL Microbiology Miscellaneous Mucosa Mucous Membrane - cytology Mucous Membrane - immunology T lymphocytes T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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