Discovery of Mouse Spleen Signaling Responses to Anthrax using Label-Free Quantitative Phosphoproteomics via Mass Spectrometry

Inhalational anthrax is caused by spores of the bacterium Bacillus anthracis (B. anthracis), and is an extremely dangerous disease that can kill unvaccinated victims within 2 weeks. Modern antibiotic-based therapy can increase the survival rate to ∼50%, but only if administered presymptomatically (w...

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Veröffentlicht in:	Molecular & cellular proteomics 2011-03, Vol.10 (3), p.M110.000927-M110.000927, Article M110.000927
Hauptverfasser:	Manes, Nathan P., Dong, Li, Zhou, Weidong, Du, Xiuxia, Reghu, Nikitha, Kool, Arjan C., Choi, Dahan, Bailey, Charles L., Petricoin, Emanuel F., Liotta, Lance A., Popov, Serguei G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anthrax - immunology Chromatography, Liquid Databases, Protein Humans Mass Spectrometry - methods Mice Phosphopeptides - chemistry Phosphopeptides - metabolism Phosphoproteins - chemistry Phosphoproteins - metabolism Proteomics - methods Signal Transduction - immunology Spleen - immunology Staining and Labeling
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