Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clari...

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Veröffentlicht in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2009-05, Vol.18 (5), p.1544-1551
Hauptverfasser: BERTHILLER, Julien, LEE, Yuan-Chin Amy, CHU CHEN, SCHWARTZ, Stephen M, ELUF NETO, José, WÜNSCH FILHO, Victor, KOIFMAN, Sergio, CURADO, Maria Paula, MATOS, Elena, FEMANDEZ, Leticia, MENEZES, Ana, DAUDT, Alexander W, BOFFETTA, Paolo, FERRO, Gilles, BRENNAN, Paul, HASHIBE, Mia, QINGYI WEI, STURGIS, Erich M, GREENLAND, Sander, MORGENSTERN, Hal, ZHANG, Zuo-Feng, LAZARUS, Philip, MUSCAT, Joshua
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container_end_page 1551
container_issue 5
container_start_page 1544
container_title Cancer epidemiology, biomarkers & prevention
container_volume 18
creator BERTHILLER, Julien
LEE, Yuan-Chin Amy
CHU CHEN
SCHWARTZ, Stephen M
ELUF NETO, José
WÜNSCH FILHO, Victor
KOIFMAN, Sergio
CURADO, Maria Paula
MATOS, Elena
FEMANDEZ, Leticia
MENEZES, Ana
DAUDT, Alexander W
BOFFETTA, Paolo
FERRO, Gilles
BRENNAN, Paul
HASHIBE, Mia
QINGYI WEI
STURGIS, Erich M
GREENLAND, Sander
MORGENSTERN, Hal
ZHANG, Zuo-Feng
LAZARUS, Philip
MUSCAT, Joshua
description Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals (95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1544–51)
doi_str_mv 10.1158/1055-9965.EPI-08-0845
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Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals (95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol. 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Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals (95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol. 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prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERTHILLER, Julien</au><au>LEE, Yuan-Chin Amy</au><au>CHU CHEN</au><au>SCHWARTZ, Stephen M</au><au>ELUF NETO, José</au><au>WÜNSCH FILHO, Victor</au><au>KOIFMAN, Sergio</au><au>CURADO, Maria Paula</au><au>MATOS, Elena</au><au>FEMANDEZ, Leticia</au><au>MENEZES, Ana</au><au>DAUDT, Alexander W</au><au>BOFFETTA, Paolo</au><au>FERRO, Gilles</au><au>BRENNAN, Paul</au><au>HASHIBE, Mia</au><au>QINGYI WEI</au><au>STURGIS, Erich M</au><au>GREENLAND, Sander</au><au>MORGENSTERN, Hal</au><au>ZHANG, Zuo-Feng</au><au>LAZARUS, Philip</au><au>MUSCAT, Joshua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium</atitle><jtitle>Cancer epidemiology, biomarkers &amp; prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>18</volume><issue>5</issue><spage>1544</spage><epage>1551</epage><pages>1544-1551</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals (95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1544–51)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19423532</pmid><doi>10.1158/1055-9965.EPI-08-0845</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research
subjects Adult
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
Female
head and neck cancer
Head and Neck Neoplasms - epidemiology
Humans
Interviews as Topic
Latin America - epidemiology
Logistic Models
Male
marijuana
Marijuana Smoking - adverse effects
Marijuana Smoking - epidemiology
Medical sciences
Middle Aged
pooled analysis
Risk Factors
Smoking - adverse effects
Smoking - epidemiology
Tobacco, tobacco smoking
Toxicology
Tumors
United States - epidemiology
title Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium
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