The Glutamate Agonist Homocysteine Sulfinic Acid Stimulates Glucose Uptake through the Calcium-dependent AMPK-p38 MAPK-Protein Kinase C ζ Pathway in Skeletal Muscle Cells

Homocysteine sulfinic acid (HCSA) is a homologue of the amino acid cysteine and a selective metabotropic glutamate receptor (mGluR) agonist. However, the metabolic role of HCSA is poorly understood. In this study, we showed that HCSA and glutamate stimulated glucose uptake in C2C12 mouse myoblast ce...

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Veröffentlicht in:	The Journal of biological chemistry 2011-03, Vol.286 (9), p.7567-7576
Hauptverfasser:	Kim, Ji Hae, Lee, Jung Ok, Lee, Soo Kyung, Moon, Ji Wook, You, Ga Young, Kim, Su Jin, Park, Sun-Hwa, Park, Ji Man, Lim, Se Young, Suh, Pann-Ghill, Uhm, Kyung-Ok, Song, Min Seok, Kim, Hyeon Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated Protein Kinase (AMPK) Animals Calcium Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cells, Cultured Diabetes Glucose - pharmacokinetics Glucose Metabolism Glucose Transporter Type 4 - metabolism Glutamate Homocysteine - analogs & derivatives Homocysteine - metabolism Homocysteine - pharmacology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - enzymology Muscle, Skeletal - cytology Muscle, Skeletal - enzymology p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - physiology Protein Kinase C - genetics Protein Kinase C - metabolism Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Signal Transduction
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