The anatomy underlying acute versus chronic spatial neglect: a longitudinal study
Our aim was to examine how brain imaging in the initial phase of a stroke could predict both acute/subacute as well as chronic spatial neglect. We present the first voxel-wise longitudinal lesion-behaviour mapping study, examining acute/subacute as well as chronic performance in the same individuals...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2011-03, Vol.134 (Pt 3), p.903-912 |
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| creator | KARNATH, Hans-Otto RENNIG, Johannes JOHANNSEN, Leif RORDEN, Chris |
| description | Our aim was to examine how brain imaging in the initial phase of a stroke could predict both acute/subacute as well as chronic spatial neglect. We present the first voxel-wise longitudinal lesion-behaviour mapping study, examining acute/subacute as well as chronic performance in the same individuals. Acute brain imaging (acquired on average 6.2 days post-injury) was used to evaluate neglect symptoms at the initial (mean 12.4 days post-stroke) and the chronic (mean 491 days) phase of the stroke. Chronic neglect was found in about one-third of the patients with acute neglect. Analysis suggests that lesion of the superior and middle temporal gyri predict both acute/subacute as well as chronic neglect. At the subcortical level, the basal ganglia as well as the inferior occipitofrontal fasciculus/extreme capsule appear to play a significant role for both acute/subacute as well as chronic neglect. Beyond, the uncinate fasciculus was critically related to the emergence of chronic spatial neglect. We infer that individuals who experience spatial neglect in the initial phase of the stroke yet do not have injury to these cortical and subcortical structures are likely to recover, and thus have a favourable prognosis. |
| doi_str_mv | 10.1093/brain/awq355 |
| format | Article |
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We present the first voxel-wise longitudinal lesion-behaviour mapping study, examining acute/subacute as well as chronic performance in the same individuals. Acute brain imaging (acquired on average 6.2 days post-injury) was used to evaluate neglect symptoms at the initial (mean 12.4 days post-stroke) and the chronic (mean 491 days) phase of the stroke. Chronic neglect was found in about one-third of the patients with acute neglect. Analysis suggests that lesion of the superior and middle temporal gyri predict both acute/subacute as well as chronic neglect. At the subcortical level, the basal ganglia as well as the inferior occipitofrontal fasciculus/extreme capsule appear to play a significant role for both acute/subacute as well as chronic neglect. Beyond, the uncinate fasciculus was critically related to the emergence of chronic spatial neglect. We infer that individuals who experience spatial neglect in the initial phase of the stroke yet do not have injury to these cortical and subcortical structures are likely to recover, and thus have a favourable prognosis.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awq355</identifier><identifier>PMID: 21156661</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acute Disease ; Aged ; Anatomy ; Biological and medical sciences ; Brain Mapping - methods ; Central nervous system ; Cerebral Cortex - pathology ; Chronic Disease ; Female ; Functional Laterality - physiology ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neurology</subject><subject>Original</subject><subject>Perceptual Disorders - pathology</subject><subject>Perceptual Disorders - physiopathology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0cFvFCEUBnDSaOy2evNsuBgvHQs8GIYeTEyjrUkTY1LP5JVhdjEss4WZmv3vpe7a6qmeIPDLFx4fIa85e8-ZgdObjCGd4s9bUOqALLhsWSO4ap-RBWOsbTqj2CE5KuUHY1yCaF-QQ8EraFu-IN-uV55iwmlcb-mcep_jNqQlRTdPnt75XOZC3SqPKThaNjgFjDT5ZfRuOqNI45iWYZr7kOp5qZvtS_J8wFj8q_16TL5__nR9ftlcfb34cv7xqnFKwtTgIDoORspecvCDMLIFBrxnCKwHbRw4PQgGrUaupOyUdp57rZwatMG-g2PyYZe7mW_Wvnc-TRmj3eSwxry1Iwb7700KK7sc7yywGidMDXi3D8jj7ezLZNehOB8jJj_OxRqm6y_p_5WSCfGk7OrsWvHuXp7spMtjKdkPDy_nzN4Xa38Xa3fFVv7m72kf8J8mK3i7B1gcxiFjcqE8OjAguNTwCycGra4</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>KARNATH, Hans-Otto</creator><creator>RENNIG, Johannes</creator><creator>JOHANNSEN, Leif</creator><creator>RORDEN, Chris</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>The anatomy underlying acute versus chronic spatial neglect: a longitudinal study</title><author>KARNATH, Hans-Otto ; RENNIG, Johannes ; JOHANNSEN, Leif ; RORDEN, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-af2813944d413ef29463031d0a30d379c3c7f20367a1544857ce1e75c5f79ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Anatomy</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping - methods</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - pathology</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. 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We present the first voxel-wise longitudinal lesion-behaviour mapping study, examining acute/subacute as well as chronic performance in the same individuals. Acute brain imaging (acquired on average 6.2 days post-injury) was used to evaluate neglect symptoms at the initial (mean 12.4 days post-stroke) and the chronic (mean 491 days) phase of the stroke. Chronic neglect was found in about one-third of the patients with acute neglect. Analysis suggests that lesion of the superior and middle temporal gyri predict both acute/subacute as well as chronic neglect. At the subcortical level, the basal ganglia as well as the inferior occipitofrontal fasciculus/extreme capsule appear to play a significant role for both acute/subacute as well as chronic neglect. Beyond, the uncinate fasciculus was critically related to the emergence of chronic spatial neglect. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute Disease Aged Anatomy Biological and medical sciences Brain Mapping - methods Central nervous system Cerebral Cortex - pathology Chronic Disease Female Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Nerve Fibers, Myelinated - pathology Neurology Original Perceptual Disorders - pathology Perceptual Disorders - physiopathology Time Factors Vertebrates: nervous system and sense organs |
| title | The anatomy underlying acute versus chronic spatial neglect: a longitudinal study |
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