Simultaneous Electrical and Optical Measurements Show that Membrane Fusion Precedes Secretory Granule Swelling during Exocytosis of Beige Mouse Mast Cells

Mast cells show dramatic morphological changes when undergoing exocytosis. We have investigated whether the first of those morphological changes, swelling of the secretory granule, precedes--and therefore possibly initiates--secretion or whether it occurs after fusion of the granule and plasma membr...

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