Progress and prospects: immune responses to viral vectors
Viral vectors are potent gene delivery platforms used for the treatment of genetic and acquired diseases. However, just as viruses have evolved to infect cells efficiently, the immune system has evolved to fight off what it perceives as invading pathogens. Therefore, innate immunity and antigen-spec...
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| Veröffentlicht in: | Gene therapy 2010-03, Vol.17 (3), p.295-304 |
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| description | Viral vectors are potent gene delivery platforms used for the treatment of genetic and acquired diseases. However, just as viruses have evolved to infect cells efficiently, the immune system has evolved to fight off what it perceives as invading pathogens. Therefore, innate immunity and antigen-specific adaptive immune responses against vector-derived antigens reduce the efficacy and stability of
in vivo
gene transfer. In addition, a number of vectors are derived from parent viruses that humans encounter through natural infection, resulting in preexisting antibodies and possibly in memory responses against vector antigens. Similarly, antibody and T-cell responses may be directed against therapeutic gene products that often differ from the endogenous nonfunctional or absent protein that is being replaced. As details and mechanisms of such immune reactions are uncovered, novel strategies are being developed, and vectors are being specifically engineered to avoid, suppress or manipulate the response, ideally resulting in sustained expression and immune tolerance to the transgene product. This review provides a summary of our current knowledge of the interactions between the immune system adeno-associated virus, adenoviral and lentiviral vectors, and their transgene products. |
| doi_str_mv | 10.1038/gt.2009.148 |
| format | Article |
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in vivo
gene transfer. In addition, a number of vectors are derived from parent viruses that humans encounter through natural infection, resulting in preexisting antibodies and possibly in memory responses against vector antigens. Similarly, antibody and T-cell responses may be directed against therapeutic gene products that often differ from the endogenous nonfunctional or absent protein that is being replaced. As details and mechanisms of such immune reactions are uncovered, novel strategies are being developed, and vectors are being specifically engineered to avoid, suppress or manipulate the response, ideally resulting in sustained expression and immune tolerance to the transgene product. This review provides a summary of our current knowledge of the interactions between the immune system adeno-associated virus, adenoviral and lentiviral vectors, and their transgene products.</description><identifier>ISSN: 0969-7128</identifier><identifier>EISSN: 1476-5462</identifier><identifier>DOI: 10.1038/gt.2009.148</identifier><identifier>PMID: 19907498</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adaptive immunity ; Adeno-associated virus ; Adenoviridae - immunology ; Adenoviruses ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Antibodies, Viral - immunology ; Antigens ; Antigens, Viral - immunology ; Applied cell therapy and gene therapy ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; Complement System Proteins - immunology ; Dependovirus - immunology ; Expression vectors ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Gene Therapy ; Gene transfer ; Genetic aspects ; Genetic Therapy ; Genetic Vectors - immunology ; Health aspects ; Health. Pharmaceutical industry ; Human Genetics ; Humans ; Immune response ; Immune system ; Immune Tolerance ; Immunity, Innate ; Immunological memory ; Immunological tolerance ; Industrial applications and implications. Economical aspects ; Innate immunity ; Lentivirus - immunology ; Lymphocytes T ; Medical sciences ; Mice ; Nanotechnology ; Pathogens ; Physiological aspects ; review ; T-Lymphocytes - immunology ; Toll-Like Receptor 9 - immunology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Vectors (Biology) ; Viruses</subject><ispartof>Gene therapy, 2010-03, Vol.17 (3), p.295-304</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><rights>Macmillan Publishers Limited 2010.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c732t-c79c2f34d3bb011859bd89583cf2aef58092742030030e2e0d088ccd60f0f2dc3</citedby><cites>FETCH-LOGICAL-c732t-c79c2f34d3bb011859bd89583cf2aef58092742030030e2e0d088ccd60f0f2dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gt.2009.148$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gt.2009.148$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22483563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19907498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nayak, S</creatorcontrib><creatorcontrib>Herzog, R W</creatorcontrib><title>Progress and prospects: immune responses to viral vectors</title><title>Gene therapy</title><addtitle>Gene Ther</addtitle><addtitle>Gene Ther</addtitle><description>Viral vectors are potent gene delivery platforms used for the treatment of genetic and acquired diseases. However, just as viruses have evolved to infect cells efficiently, the immune system has evolved to fight off what it perceives as invading pathogens. Therefore, innate immunity and antigen-specific adaptive immune responses against vector-derived antigens reduce the efficacy and stability of
in vivo
gene transfer. In addition, a number of vectors are derived from parent viruses that humans encounter through natural infection, resulting in preexisting antibodies and possibly in memory responses against vector antigens. Similarly, antibody and T-cell responses may be directed against therapeutic gene products that often differ from the endogenous nonfunctional or absent protein that is being replaced. As details and mechanisms of such immune reactions are uncovered, novel strategies are being developed, and vectors are being specifically engineered to avoid, suppress or manipulate the response, ideally resulting in sustained expression and immune tolerance to the transgene product. This review provides a summary of our current knowledge of the interactions between the immune system adeno-associated virus, adenoviral and lentiviral vectors, and their transgene products.</description><subject>Adaptive immunity</subject><subject>Adeno-associated virus</subject><subject>Adenoviridae - immunology</subject><subject>Adenoviruses</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigens</subject><subject>Antigens, Viral - immunology</subject><subject>Applied cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Complement System Proteins - immunology</subject><subject>Dependovirus - immunology</subject><subject>Expression vectors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Gene transfer</subject><subject>Genetic aspects</subject><subject>Genetic Therapy</subject><subject>Genetic Vectors - immunology</subject><subject>Health aspects</subject><subject>Health. Pharmaceutical industry</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immune Tolerance</subject><subject>Immunity, Innate</subject><subject>Immunological memory</subject><subject>Immunological tolerance</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Innate immunity</subject><subject>Lentivirus - immunology</subject><subject>Lymphocytes T</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nanotechnology</subject><subject>Pathogens</subject><subject>Physiological aspects</subject><subject>review</subject><subject>T-Lymphocytes - immunology</subject><subject>Toll-Like Receptor 9 - immunology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Vectors (Biology)</subject><subject>Viruses</subject><issn>0969-7128</issn><issn>1476-5462</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFktuLEzEUxoMobq0--S6Di4poa24zk_ggLIuXhQXFy3NIM5lplplkTDJF_3tPadluZUUSEsj5nS_JOR9CjwleEszEmy4vKcZySbi4g2aE19Wi5BW9i2ZYVnJREypO0IOUrjDGvBb0PjohUuKaSzFD8ksMXbQpFdo3xRhDGq3J6W3hhmHytoDQGHyyqcih2Lio-2IDQIjpIbrX6j7ZR_t9jn58eP_9_NPi8vPHi_Ozy4WpGc2wSkNbxhu2WmFCRClXjZClYKal2ralwJLWnGKGYVpqcYOFMKapcItb2hg2R-92uuO0GmxjrM_wCjVGN-j4WwXt1HHEu7XqwkYxzDn8EQRe7AVi-DnZlNXgkrF9r70NU1I1rxguJaP_JxmjkpXw2Dk6_Yu8ClP0UAdFK84rXlLOgHr6T4qImnDCy4NUp3urnG8D_MJsL1ZnlJKqrKG7QC1voWA0dnAmeNs6OD9KeHmUAEy2v3Knp5TUxbevx-zzG-za6j6vU-in7KD1x-CrHWjAKCna9roNBKutGVWX1daMCswI9JObnTuwe_cB8GwP6GR030btjUvXHKUgUlbbOr7ecQlCvrPxUMfb7v0DMgbwag</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Nayak, S</creator><creator>Herzog, R W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>7T5</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Progress and prospects: immune responses to viral vectors</title><author>Nayak, S ; Herzog, R W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c732t-c79c2f34d3bb011859bd89583cf2aef58092742030030e2e0d088ccd60f0f2dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptive immunity</topic><topic>Adeno-associated virus</topic><topic>Adenoviridae - immunology</topic><topic>Adenoviruses</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Antibodies, Viral - immunology</topic><topic>Antigens</topic><topic>Antigens, Viral - immunology</topic><topic>Applied cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cell Biology</topic><topic>Complement System Proteins - immunology</topic><topic>Dependovirus - immunology</topic><topic>Expression vectors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Gene Therapy</topic><topic>Gene transfer</topic><topic>Genetic aspects</topic><topic>Genetic Therapy</topic><topic>Genetic Vectors - immunology</topic><topic>Health aspects</topic><topic>Health. Pharmaceutical industry</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immune Tolerance</topic><topic>Immunity, Innate</topic><topic>Immunological memory</topic><topic>Immunological tolerance</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Innate immunity</topic><topic>Lentivirus - immunology</topic><topic>Lymphocytes T</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nanotechnology</topic><topic>Pathogens</topic><topic>Physiological aspects</topic><topic>review</topic><topic>T-Lymphocytes - immunology</topic><topic>Toll-Like Receptor 9 - immunology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Vectors (Biology)</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nayak, S</creatorcontrib><creatorcontrib>Herzog, R W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nayak, S</au><au>Herzog, R W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progress and prospects: immune responses to viral vectors</atitle><jtitle>Gene therapy</jtitle><stitle>Gene Ther</stitle><addtitle>Gene Ther</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>17</volume><issue>3</issue><spage>295</spage><epage>304</epage><pages>295-304</pages><issn>0969-7128</issn><eissn>1476-5462</eissn><abstract>Viral vectors are potent gene delivery platforms used for the treatment of genetic and acquired diseases. However, just as viruses have evolved to infect cells efficiently, the immune system has evolved to fight off what it perceives as invading pathogens. Therefore, innate immunity and antigen-specific adaptive immune responses against vector-derived antigens reduce the efficacy and stability of
in vivo
gene transfer. In addition, a number of vectors are derived from parent viruses that humans encounter through natural infection, resulting in preexisting antibodies and possibly in memory responses against vector antigens. Similarly, antibody and T-cell responses may be directed against therapeutic gene products that often differ from the endogenous nonfunctional or absent protein that is being replaced. As details and mechanisms of such immune reactions are uncovered, novel strategies are being developed, and vectors are being specifically engineered to avoid, suppress or manipulate the response, ideally resulting in sustained expression and immune tolerance to the transgene product. This review provides a summary of our current knowledge of the interactions between the immune system adeno-associated virus, adenoviral and lentiviral vectors, and their transgene products.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19907498</pmid><doi>10.1038/gt.2009.148</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adaptive immunity Adeno-associated virus Adenoviridae - immunology Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies, Viral - immunology Antigens Antigens, Viral - immunology Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Complement System Proteins - immunology Dependovirus - immunology Expression vectors Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Therapy Genetic Vectors - immunology Health aspects Health. Pharmaceutical industry Human Genetics Humans Immune response Immune system Immune Tolerance Immunity, Innate Immunological memory Immunological tolerance Industrial applications and implications. Economical aspects Innate immunity Lentivirus - immunology Lymphocytes T Medical sciences Mice Nanotechnology Pathogens Physiological aspects review T-Lymphocytes - immunology Toll-Like Receptor 9 - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vectors (Biology) Viruses |
| title | Progress and prospects: immune responses to viral vectors |
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