IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-alpha therapy

Interferon-α (IFN-α) treatment for hepatitis C virus (HCV) is complicated by depression and related neurovegetative side effects. Recent genome-wide scans identified IL28B gene polymorphisms that associated with HCV clearance. Whether the IL28B polymorphism is also associated with these adverse effe...

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Veröffentlicht in:	Journal of interferon & cytokine research 2011-03, Vol.31 (3), p.331-336
Hauptverfasser:	Lotrich, Francis E, Loftis, Jennifer M, Ferrell, Robert E, Rabinovitz, Mordechai, Hauser, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Drug therapy Female Genetic aspects Genetic polymorphisms Genotype Health aspects Hepacivirus Hepatitis C Hepatitis C - drug therapy Hepatitis C - genetics Hepatitis C virus Humans Interferon alpha Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Interferons Interleukins Interleukins - genetics Male Middle Aged Physiological aspects Polymorphism, Single Nucleotide Research Reports
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