Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway

Diarrhea is a common manifestation of gastrointestinal disorders. Diarrhea-induced losses of fluid and electrolyte could lead to dehydration and electrolyte imbalances, resulting in significant morbidity and mortality, especially in children living in developing countries. Somatostatin, a peptide ho...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2011-02, Vol.300 (2), p.C375-C382
Hauptverfasser:	Wang, Chunhui, Xu, Hua, Chen, Huacong, Li, Jing, Zhang, Bo, Tang, Chengwei, Ghishan, Fayez K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiarrheals - pharmacology Caco-2 Cells Cell Line Cells Diarrhea Female Gene expression Humans Intestinal Absorption - drug effects Intestine, Small - drug effects Intestine, Small - metabolism Membrane Transporters, Ion Channels and Pumps Membranes Mice Microvilli - metabolism Octreotide - pharmacology Oligopeptides - pharmacology p38 Mitogen-Activated Protein Kinases - analysis p38 Mitogen-Activated Protein Kinases - metabolism Peptides Phosphorylation - drug effects Physiology Receptors, Somatostatin - antagonists & inhibitors Signal transduction Sodium - metabolism Sodium-Hydrogen Exchangers - analysis Sodium-Hydrogen Exchangers - metabolism Somatostatin - pharmacology
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